严诗楷 副研究员

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邮箱：shkyan@sjtu.edu.cn



个人简历 研究方向 发表论文
荷兰莱顿大学生物研究所访问****（2014-2015），新疆维吾尔医学专科学校挂职干部（2016-2017）。曾获上海交通大学“晨星青年****奖励计划”SMC优秀青年教师奖（2010），参研项目“方剂组分活性跟踪与配伍方法的建立与实践”获国家科技进步二等奖（2006）；主持或合作参与上海市科委“科技创新行动”中药现代化专项、国家自然科学基金重点项目、面上项目、企业横向课题等科研项目10项。累计发表论文120余篇（包括SCI收录期刊论文100篇以上），其中以第一作者（含共同第一作者）及通讯作者身份在Journal of Hepatology, Journal of Proteome Research, International Journal of Cancer, Oncotarget, Oral Oncology, Journal of Chromatography A等国际知名期刊发表SCI论文30余篇，单篇最高影响因子12.49。

1、整合多组学分析技术与网络生物学的中医药研究新方法； 2、重大非传染性慢性疾病的精准诊断、分子分型与中西医结合防控策略； 3、南疆特色药用资源开发与维药新药研究； 4、中药与民族药物的药效物质基础与质量标准研究； 5、糖脂代谢病创新理论与“调肝启枢化浊”防控的基础与临床研究；

First Author or Co-First Author Yang F, Yan SK, He Y, Wang F, Song SX, Guo YJ, Zhou Q, Wang Y, Lin ZY, Yang Y, Zhang WD, Sun SH. Expression of hepatitis B virus proteins in transgenic mice alters lipid metabolism and induces oxidative stress in the liver.Journal of Hepatology2008; 48(1): 12-19 (Co-First Author;IF=12.486) YAN Shi-Kai, LIU Run-Hui, JIN Hui-Zi, LIU Xin-Ru, YE Ji, SHAN Lei, ZHANG Wei-Dong*, “Omics” in pharmaceutical research: overview, applications, challenges, and future perspectives. Chinese Journal of Natural Medicines 2015, 13(1): 3~21(IF=1.667) Yang F, Yan SK, Wang F, He Y, Guo YJ, Zhou Q, Wang Y, Zhang XY, Zhang WD, Sun SH. DNA immunization perturbs lipid metabolites and increases risk of atherogenesis.Journal of Proteome Research2008; 7(2): 741-748 (Co-First Author; IF=4.268) Yuan X, Yan SK, Zhao J, Shi D, Yuan B, Dai WX, Jiao BH, Zhang WD, Miao MY. Lipid Metabolism and Peroxisome Proliferator-Activated Receptor Signaling Pathways Participate in Late-Phase Liver Regeneration.Journal of Proteome Research2011; 10(3): 1179-1190 (Co-First Author; IF=4.268) Yan SK, Wei BJ, Lin ZY, Yang Y, Zhou ZT, Zhang WD. A metabonomic approach to the diagnosis of oral squamous cell carcinoma, oral lichen planus and oral leukoplakia.Oral Oncology2008; 44(5): 477-483 (IF=4.794) Yan SK, Xin WF, Luo GA, Wang YM, Cheng YY. An approach to develop two-dimensional fingerprint for the quality control of Qingkailing injection by high-performance liquid chromatography with diode array detection.Journal of Chromatography A2005; 1090(1-2): 90-97 (IF=3.981)? Yan SK, Wu B, Lin ZY, Jin HZ, Huang JH, Yang Y, Zhang XM, Shen ZY, Zhang WD. Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium.Molecular Biosystems2009; 5(10): 1204-1213 (IF=3.534) Wang X, Yan SK, Dai WX, Liu XR, Zhang WD, Wang JJ. A metabonomic approach to chemosensitivity prediction of cisplatin plus 5-fluorouracil in a human xenograft model of gastric cancer.International Journal of Cancer2010; 127(12): 2841-2850 (Co-First Author; IF=6.513) Wu B, Yan SK, Lin ZY, Wang Q, Yang Y, Yang GJ, Shen ZY, Zhang WD. Metabonomic study on ageing: NMR-based investigation into rat urinary metabolites and the effect of the total flavone of Epimedium.Molecular Biosystems2008; 4(8): 855-861 (Co-First Author; IF=3.534) Yan SK, Luo GA, Wang YM, Cheng YY. Simultaneous determination of nine components inQingkailinginjection by HPLC/ELSD/DAD and its application to the quality control.Journal of Pharmaceutical and Biomedical Analysis2006; 40(4): 889-895 (IF=3.255) Yan SK, Luo GA, Wang YM, Cheng YY. Study on real-time control of extraction procedure of furitus gardenia by near infrared spectroscopy.Spectroscopy and Spectral Analysis2006; 26(6): 1026-1030 (IF=0.344) Yan SK, Wu YW, Liu RH, Zhang WD. Comparative study on major bioactive components in natural, artificial and in-vitro cultured Calculus Bovis.Chemical & Pharmaceutical Bulletin2007; 55(1): 128-132 (IF=1.592) Yan SK, Xin WF, Luo GA, Wang YM, Cheng YY. Simultaneous determination of major bioactive components in Qingkailing injection by high-performance liquid chromatography with evaporative light scattering detection.Chemical & Pharmaceutical Bulletin2005; 53(11): 1392-1395 (IF=1.592;) Yan SK, Xin WF, Luo GA, Wang YM, Cheng YY. Chemical fingerprinting of Gardenia jasminoides fruit using direct sample introduction and gas chromatography with mass spectrometry detection.Journal of AOAC International2006; 89: 40-45 (IF=1.199) Yan SK, Zhang WD, Liu RH, Zhan YC. Chemical fingerprinting of ShexiangBaoxin Pill and simultaneous determination of its major constituents by HPLC with evaporative light scattering detection and electrospray mass spectrometric detection.Chemical & Pharmaceutical Bulletin2006; 54(7): 1058-1062. (IF=1.592) Zhang YW, Yan SK, Gao X, Xiong XS, Dai WX, Liu XR, Zhang WD, Mei CL. Analysis of urinary metabolic profile in aging rats undergoing caloric restriction.Aging Clinical and Experimental Research2012; 24(1): 79-84 (Co-First Author; IF=1.552) Liu Y, Yan SK, Ji CC, Dai WX, Hu WJ, Zhang WD, Mei CL. Metabolomic Changes and Protective Effect of L-Carnitine in Rat Kidney Ischemia/Reperfusion Injury.Kidney & Blood Pressure Research2012; 35(5): 373-381 (Co-First Author; IF=1.464) Zhang YW, Yan SK, Gao X, Dai WX, Liu SY, Jin H, Zhang WD, Mei CL. Metabonomic investigation on the protective effects of rosiglitazone and caloric restriction for renal senescence in a rat model. Aging Clinical and Experimental Research.2012, 24(5): 430-438 (Co-First Author; IF=1.552) Shikai Yan, Yun Yang, Yanwen Wu, et al. Chemical Fingerprinting and Quantitative Analysis of Volatiles in ShexiangBaoxin Pill by Gas Chromatography with Flame Ionization and Mass Spectrometric Detection. Journal of Analytical Chemistry, 2009, 64: 141-148 (IF=0.747) Shikai Yan, Zhongying Lin, Weixing Dai, et al. Chemometrics-based Approach to Modeling Quantitative Composition-activity Relationships for Radix Tinosporae. Interdisciplinary Sciences- Computational Life Sciences. 2010, 2: 221-227（IF=0.753） 严诗楷,赵静, 窦圣姗等. 基于系统生物学与网络生物学的现代中药复方研究体系. 中国天然药物. 2009, 7(4): 249-259 Corresponding Author or Co-corresponding Author Xia XL, Jin HZ, Yan SK, Zhang WD. Analysis of the bioactive constituents of ChanSu in rat plasma by high performance liquid chromatography with mass spectrometric detection.Journal of Pharmaceutical and Biomedical Analysis2010; 53:646-654 (IF=2.967) Liang S, Shen YH, Tian JM, Wu ZJ, Jin HZ, Zhang WD, Yan SK. Phenylpropanoids from Daphne feddei and Their Inhibitory Activities against NO Production.Journal of Natural Products2008; 71(11): 1902-1905 (IF=3.128) Liang S, Shen YH, Tian JM, Wu ZJ, Jin HZ, Zhang WD, Yan SK. Three New Dicoumarins from Daphne feddei.Helvetica ChimicaActa2009; 92(1): 133-138 (IF=1.478) Liang S, Tang J, Shen YH, Jin HZ, Tian JM, Wu ZJ, Zhang WD, Yan SK. Biflavonoids from Daphne feddei and Their Inhibitory Activities against Nitric Oxide Production.Chemical & Pharmaceutical Bulletin2008; 56(12): 1729-1731? (IF=1.592) Qin JJ, Jin HZ, Fu JJ, Hu XJ, Wang Y, Yan SK, Zhang WD. Japonicones A-D, bioactive dimericsesquiterpenes from Inula japonica Thunb. Bioorganic & Medicinal Chemistry Letters2010; 20(18): 5584-5584 （IF=2.554） Lei Zhou, Zeyong Yang, Xianfu Lu, Xingxing Li, Xiaohu An, Jing Chai, Qiling Yang, Shikai Yan and Yuanhai Li, JNK inhibitor alleviates apoptosis of fetal neural stem cells induced by emulsified isoflurane, Oncotarget, 2017, 8 (55): 94009~94019(IF=5.178) Jialong Jiang, Shasha Li, Yiqiao Wang, Xue Xiao, Yi Jin, Yilong Wang, Zeyong Yang,? Shikai Yan, Yuanhai Li,? Potential neurotoxicity of prenatal exposure to sevoflurane on offspring: Metabolomics investigation on neurodevelopment and underlying mechanism, International Journal of Developmental Neuroscience,2017, 62: 46~53 (IF=2.046) Xincai Zhao, YigongGuo, Yu Zhang, YangguoXie, Shikai Yan, Huizi Jin,Weidong Zhang, Monoterpene derivatives from the flowers of the Hemerocallis minor Mill. Phytochemistry Letters 2017,21: 134–138 (IF=1.418)