赵文娟 副研究员

电话：
邮箱：zhaowj@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
赵文娟：博士，副研究员，硕士生导师。2008年获上海交通大学药学院博士学位；2011-2014在美国乔治城大学神经科学系从事博士后研究工作。1999-2003年在中科院上海生命科学院细胞生物学研究所工作；2003年进入上海交通大学药学院工作至今。研究方向为神经退行性疾病及慢性炎症性疾病的发病机理，发现潜在的药物靶标。在Hum. Mol. Genet，Mol Nutr Food Res等杂志发表科研SCI论文20余篇，荣获2010年“中国药理学会施维雅青年药理学工作者奖”。中国老年医学学会基础与转化医学分会第一届青年委员会委员。主持国家自然基金面上项目2项，教育部新教师基金1项。参与《人民卫生出版社国家医学教育题库(药学专业题库) 》中《药理学》的命题工作。
学术兼职情况：
1.中国老年医学学会基础与转化医学分会第一届青年委员会委员

教学情况：
1.培养硕士研究生5名，其中已经硕士毕业4名。
2.培养上海市优秀毕业生1名，上海交通大学优秀毕业生1名，2人荣获国家奖学金等荣誉。
3.主讲本科生通识核心课程《脑与日常行为》，参讲《药理学（双语教学）》和《药物研发试验》等课程。
4.参编《人民卫生出版社国家医学教育题库（药学专业题库）》（ISBN978-7-89456-772-7）中《药理学》，2020年4月题库上线。


1.神经药理学方向：利用特异性基因替代及转基因动物，在分子、细胞及整体动物水平研究阿尔茨海默病、帕金森病等神经退行性疾病的发病机制，发现潜在药物靶点，进行新药研发和诊断试剂开发。
2.免疫药理学方向：运用基因敲除小鼠和炎症动物模型，阐明炎症微环境调控疾病的分子病理机制以及炎症细胞的活化机制。

已发表SCI研究论文：
（1）Jinchao Gao, Lidong Zhao (co-first author), Jinfeng Wang, Lihang Zhang, Dandan Zhou, Jinlong Qu, Hao Wang, Ming Yin, Jiang Hong *, Wenjuan Zhao*. C Phycocyanin ameliorates mitochondrial fission and fusion dynamics in ischemic cardiomyocyte damage. Frontiers in Pharmacology. Front Pharmacol. 2019; 10: 733.
（2） Lihang Zhang #, Juan Xu #, Jinchao Gao, Peiqing Chen, Ming Yin*, Wenjuan Zhao*. Decreased immunoglobulin G in brain regions of elder female APOE4-TR mice accompany with Abeta accumulation. Immun Ageing, 2019.1.25;16:2.
（3）Lidong Zhao, Jinqiang Zhuang, Yihui Wang, Dandan Zhou, Dandan Zhao, Shun Zhu, Jinjun Pu, Hongyu Zhang, Ming Yin, Wenjuan Zhao, Zejian Wang* and Jiang Hong*. Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission. Front Pharmacol 2019, 10: 61.
（4）Lihang Zhang, Juan Xu, Jinchao Gao, Yuncheng Wu, Ming Yin*, Wenjuan Zhao*. CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease. Reviews in the Neurosciences, 2018.5.5, 29(8): 837-848.
（5）Yanjie Guo, Suyan Dong, Xinxin Cui, Ya Feng, Te Liu, Ming Yin, Shenghan Kuo, Wenjuan Zhao* and Yuncheng Wu*. Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3. Mol Nutr Food Res. 2016 t; 60(10):2161-2175.
（6）Peiqing Chen, Wenjuan Zhao*, Yanjie Guo, Juan Xu, and Ming Yin*. CX3CL1/CX3CR1 in Alzheimer's Disease: A Target for Neuroprotection. Biomed Res Int. 2016; 2016: **.
（7）Yanjie Guo, Suyan Dong, Xinxin Cui, Ya Feng, Te Liu, Ming Yin, Shenghan Kuo, Wenjuan Zhao*, Yuncheng Wu *. Resveratrol alleviates MPTP-induced motor impairments and pathological changes by autophagic degradation of α-synuclein via SIRT1-deacetylated LC3. Mol Nutr Food Res. 2016; 60(10): 2161-2175.
（8）Peiqing Chen, Yanjie Guo, Juan Xu, Wenjuan Zhao*, Ming Yin*. CX3CL1/CX3CR1 in Alzheimer's disease: a target for neuroprotection. Biomed Res Int. 2016; 2016: **.
（9）Ye Zhou, Wenjuan Zhao*, Nour Al-muhtasib, G William Rebeck. APOE genotype alters immunoglobulin subtypes in knock-in mice. J Alzheimers Dis. 2015; 46(2): 365-74.
（10）Lu Zhao, Sha Liu, Yin Wang, Qiaoyan Zhang, Wenjuan Zhao, Zejian Wang, Ming Yin. Effects of Curculigoside on Memory Impairment and Bone Loss via Anti-Oxidative Character in APP/PS1 Mutated Transgenic Mice. PLoS One. 2015; 10(7): e**.
（11）Wenjuan Zhao, Sonya B. Dumanis, Irfan Tamboli, Gustavo A. Rodriguez, Mary Jo LaDu, Charbel E. H. Moussa and G. William Rebeck. Human APOE Genotype Affects Intraneuronal Aβ1-42 Accumulation in a Lentiviral Gene Transfer Model. Hum Mol Genet. 2014; 3(5): 1365-1375.
（12）Wenjuan Zhao, Jiguo Zhang, Elizabeth G Davis and G William Rebeck. Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vector. Front Aging Neurosci. 2014; 6: 210.
（13）Hong Zhao, Wenjuan Zhao, Kenghoe Lok, Zejian Wang and Ming Yin. A Synergic Role of Caspase-6 and Caspase-3 in Tau Truncation at D421 Induced by H2O2. Cell Mol Neurobiol. 2014; 34(3): 369-378.
（14）Kenghoe Lok, Hong Zhao, Can Zhang, Na He, Hanlin Shen, Zejian Wang, Wenjuan Zhao*, Ming Yin *. Effects of accelerated senescence on learning and memory, locomotion and anxiety-like behavior in APP/PS1 mouse model of Alzheimer. J Neurol Sci. 2013; 335(1-2): 145-154.
（15）9. Kenghoe Lok, Hong Zhao, Hanlin Shen, Zejian Wang, Xiang Gao, Wenjuan Zhao*, Ming Yin*. Characterization of the APP/PS1 mouse model of Alzheimer's disease in senescence accelerated background. Neurosci Lett. 2013; 557 Pt B: 84-89.
（16）Huizhen Nie, Zejian Wang, Wenjuan Zhao, Jinmiao Lu, Can Zhang, Kenghoe Lok, Yuliang Wang, Hanlin Shen, Zheng Xu, Ming Yin. New nicotinic analogue ZY-1 enhances cognitive functions in a transgenic mice model of Alzheimer's disease. Neurosci Lett. 2013; 537: 29-34.
（17）Huizhen Nie, Zuoqing Li, Qixin Yan, Ronald J Lukas, Zejian Wang, Wenjuan Zhao, Lingchen Guo, Ming Yin. Nicotine Decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells. Neurochem Res. 2011; 36(5): 904-912.
（18）Wenjuan Zhao, Zhenyu Gao, Hong Wei, Huizhen Nie, Qian Zhao, Xiangjun Zhou, Yongxiang Wang. Spinal D-amino acid oxidase contributes to neuropathic pain in rats. J Pharmacol Exp Ther. 2010; 332(1):248–254.
（19）Huizhen Nie, Sha Shi, Ronald J. Lukas, Wenjuan Zhao, Yongning Sun, Ming Yin. Activation of α7 nicotinic receptor affects APP processing by regulating secretase activity in SH-EP1-α7 nAChR-hAPP695 cells. Brain Res. 2010; 1356: 112-120.
（20）Lingchen Guo, Li Song, Zejian Wang, Wenjuan Zhao, Wenwei Mao, Ming Yin. Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. Chem Biol Interact. 2009; 181: 138–143.
（21）Wenjuan Zhao, Ryuichi Konno, Xiang-Jun Zhou, Ming Yin, Yong-Xiang Wang. Inhibition of D-amino-acid oxidase activity induces pain relief in mice. Cell Mol Neurobiol. 2008; 28(4): 581-591.
（22）Hong Wei, Wenjuan Zhao, Yongxiang Wang, Antti Pertovaara. Influence of REM sleep deprivation on pain-related behavior and spinal antinociceptive effect of morphine and clonidine in two strains of neuropathic and sham control rats. Brain Res. 2007; 1148：105-112.
（23）Wenjuan Zhao, Yinghua Ma, Jian Fei, Zhentong Mei, Lihe Guo. Increase in drug-induced seizure susceptibility of transgenic mice overexpressing GABA transporter-1. Acta Pharmacol Sin. 2003; 24 (10): 991-995.
（24）Zhaoping Liu, Yan Wang, Wenjuan Zhao, Jinguo Ding, Zhentong Mei, Lihe Guo, Dafu Cui and Jian Fei. Peptide derived from insulin with regulatory activity of dopamine transporter. Neuropharmacology. 2001; 410: 464-471.
（25）Yinghua Ma, Jiahua Hu, Wenjuan Zhao, Jian Fei, Ying Yu, Xiaogang Zhou, Zhentong Mei, Lihe Guo. Overexpression of gamma-aminobutyric acid transporter subtype Ⅰ leads to susceptibility to kainic acid-induced seizure in transgenic mice. Cell Res. 2001; 11 (1): 61-67.

纵向基金资助情况：
1.国家自然科学基金面上项目（70万），主持，2015/01-2018/12（**）：人APOE4基因影响AD早期神经元内Aβ42沉积诱导小胶质细胞活化及神经炎症级联反应的分子机制。
2.国家自然科学基金面上项目（32万），主持，2010/01-2012/12（**）：活性氧调节 D421 位点tau 切割在三转基因阿尔茨海默病小鼠模型发病机制中的作用。
3.教育部新教师基金项目（3.6万），主持，2008/01-2011/12（7）：D-氨基酸氧化酶参与脊髓水平慢性疼痛中枢敏感化的机制。