朱明彦 讲师

电话：**
邮箱：myzhu@sjtu.edu.cn
主页：地址：药学院7号楼506室


个人简历 研究方向 发表论文 科研成果
教育背景
Ph.D. Organic Chemistry, Seoul National University, South Korea, 2012.
M.S. Organic Chemistry, Myong Ji University, South Korea, 2006.
B.S. Chemistry, Wuhan University, China, 2004.
工作和研究经历：
2013年4月-至今：上海交通大学药学院, 讲师，硕士生导师
主持课题：
1. 国家自然科学基金青年项目，**，半胱氨酸天冬氨酸蛋白酶-1光控分子开关的设计与合成，25万，2015/01-2017/12，已结题
2. 上海市自然科学基金，17ZR**，siRNA的分子开关和基因表达的光调控，20万，2017/05-2020/04，已结题
3. 上海交通大学医工交叉基金，新型SIRT1激活剂E4023改善脂质代谢紊乱的机理研究，2018/01-2020/12，在研
4. 上海交通大学医工交叉基金，Incarvine C调控ROCK抑制肝癌细胞株增殖与血管化拟态形成，2015/01-2017/12，已结题


药物化学，化学生物学
以活性小分子为工具对生物大分子的功能揭示和调控：1. 以具有生物活性的小分子为探针进行药物靶点发现和验证。2. 利用光控分子开关进行生物大分子活性的调控：蛋白的光控抑制剂，光控小干扰RNA。


[1]Weixiang Xin,# Zezhong Li,# Qing Wang, Jin Du, Mingyan Zhu, Huchen Zhou* Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors. Eur. J. Med. Chem. 2020, 185,111827. (IF=5.572)
[2]Zhihua Ge, Zhuojin Yang, Jingshi Liang, Duoling Dong, Mingyan Zhu* Optical Control of GTP Affinity of K-Ras(G12C) by Photoswitchable Inhibitor. ChemBioChem 2019, 20,2916 –2920. (IF=2.774)
[3]Jiong Zhang,# Jinyi Zhang,# Guiyun Hao, Weixiang Xin, Fei Yang, Mingyan Zhu, Huchen Zhou* Design, Synthesis, and Structure-Activity Relationship of 7-Propanamide Benzoxaboroles as Potent Anticancer Agents. J. Med. Chem. 2019, 62, 14, 6765–6784. (IF=6.253)
[4]Bo Li, Xiaopeng Hu, Yanzhou Yang, Mingyan Zhu, Jiong Zhang, Yanrong Wang, Xiuying Pei, Huchen Zhou*, Ji Wu* GAS5/miR-21 Axis as a Potential Target to Rescue ZCL-082-Induced Autophagy of Female Germline Stem Cells In Vitro. Mol. Ther. Nucleic Acids 2019, 17, 436-447. (IF=7.032)
[5]Xinyue Li, Xiaopeng Hu, Geng G. Tian, Ping Cheng, Zezhong Li, Mingyan Zhu, Huchen Zhou,* and Ji Wu* C89 Induces Autophagy of Female Germline Stem Cells via Inhibition of the PI3K-Akt Pathway In Vitro. Cells 2019, 8(6), 606 (IF=4.829)
[6]Mingyan Zhu, Huchen Zhou* Azobenzene-based small molecular photoswitches for protein modulation. Org. Biomol. Chem. 2018, 16(44), 8434–8445. (IF=3.423)
[7]Fei Yang, Mingyan Zhu, Jinyi Zhang, Huchen Zhou* Synthesis of biologically active boron-containing compounds. MedChemComm. 2017, 9(2), 201–211. (IF=2.342)
[8]Zhongli Wang, Wenjuan Xie, Mingyan Zhu, Huchen Zhou* Development of a highly reliable assay for ubiquitin-specific protease 2 inhibitors. Bioorg. Med. Chem. Lett. 2017, 27(17), 4015–4018. (IF=2.442)
[9]Jiong Zhang, Fei Yang, Zhitao Qiao, Mingyan Zhu, Huchen Zhou* Chalcone-benzoxaborole hybrids as novel anticancer agents. Bioorg. Med. Chem. Lett., 2016, 26(23), 5797–5801. (IF=2.442)
[10]Jiong Zhang, Mingyan Zhu, Yinan Lin, Huchen Zhou* The synthesis of benzoxaboroles and their applications in medicinal chemistry. Sci. China Chem., 2013, 56(10), 1372–1381. (IF= 4.448)
[11]Mingyan Zhu, Byung Joon Lim, Minseob Koh, Seung Bum Park* Construction of polyheterocyclic benzopyran library with diverse core skeletons through diversity-oriented synthesis pathway: part II. ACS Comb. Sci., 2012, 14(2), 124–134. (IF=3.408)
[12]Mingyan Zhu, Myung Hee Kim, Sanghee Lee, Su Jung Bae, Seong Hwan Kim*, Seung Bum Park* Discovery of novel benzopyranyl tetracycles that act as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand. J. Med. Chem., 2010, 53(24), 8760–8764. (IF=5.207)


<公开专利>
1.杨卓进, 朱明彦, 郑艺. 一种异鼠李素生物素探针及其合成方法和应用. (已申请，申请号 0X)
2.朱明彦, 东多凌, 葛志华, 杨卓进, 梁婧诗. 一种乙酰氨基偶氮苯类衍生物及其制备与应用. (CNA，已公开，公开日 2019.4.5)
3.Huchen Zhou, Zezhong Li, Jinyi Zhang, Mingyan Zhu. A new type of antitumor compounds: derivatives of 7-propanamide substituted benzoxaborole. (WO, 已公开，公开日 2020.9.24)
4.Huchen Zhou, Jiong Zhang, Mingyan Zhu, Long Ye, Yiqing Feng. Preparation of 7-propanamide substituted benzoxaboroles and their use as anticancer agents. (WOA1, 已公开，公开日 2019.8.15)
5.周虎臣, 张煚, 杨斐, 林轶男, 朱明彦. 一种苯并硼唑7位查尔酮衍生物及其制备与应用. (CNB，已授权，授权日 2020.8.25)
6. 周虎臣, 张煚, 朱明彦, 叶龙, 冯怡卿. 一种苯并硼唑7位脂肪酸的衍生物及其制备与药物用途. (CNB，已授权，授权日 2019.7.12)