张宝红 副教授

电话：
邮箱：bhzhang@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
张宝红 博士，副教授，博士生导师，教学副院长兼党委副书记，上海交通大学细胞工程及抗体药物教育部工程研究中心核心成员，负责生物技术药物和抗体药物的研发工作。2002年毕业于中国海洋大学海洋生命学院，获得博士学位。2006年赴澳大利亚La Trobe大学进修；2010年获得德国学术交流中心DAAD资助，赴德国莎尔大学医学院进修；2012年获得国家留学基金委公派访问****全额资助，在美国国立卫生研究院（NIH）进修。副主编出版《现代药物研发实践》教材一部；曾荣获上海交通大学教学成果奖一等奖1项（排名第一）、二等奖1项（排名第二）；荣获2016年上海交通大学优秀教师三等奖、上海交通大学“三八红旗手”，2017年度上海交通大学“教书育人奖”（个人奖）提名奖，2017年度上海交通大学“十佳班主任”，荣获2018 年中国产学研合作创新成果优秀奖（排名第二）。

1.新型抗体药物研发
双特异性抗体；抗体偶联药物；双特异性抗体偶联药物；人源化抗体改造
2.细胞治疗
CAR-T；干细胞等新型细胞工程治疗方法的研发
3.大规模生物药物生产工艺开发
真核表达系统的表达、纯化工艺开发
4.关键技术开发
Crisp/Cas9细胞株改造技术；哺乳动物细胞重组蛋白瞬时表达技术


1.Yunxia Li ?, Xinyu Zhang ?, Lei Wang, Huifang Zong, Yuan Yuan, Lei Han, Xi Li, Chenxiao Xu, Jingyi Zhang, Jianwei Zhu, Baohong Zhang*. Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic gene Bcl-xL combined with rapamycin. Processes. 2019, 7(6): 329; https://doi.org/10.3390/pr**.
2.Yuan Yuan, Huifang Zong, Jingyi Bai, Lei Han, Lei Wang. Xinyu Zhang, Xiaoshuai Zhang, Jingyi Zhang, Chenxiao Xu, Jianwei Zhu, Baohong Zhang*. Bioprocess development of a stable FUT8 -/--CHO cell line to produce defucosylated anti-HER2 antibody. Bioprocess and Biosystems Engineering. 2019, doi: 10.1007/s00449-019-02124-7.
3.Han L, Zong H, Zhou Y, Pan Z, Chen J, Ding K, Xie Y, Jiang H, Zhang B, Lu H, Gilly J, Zhu J. Naturally split intein Npu DnaE mediated rapid generation of bispecific IgG antibodies. Methods. 2019, 154:32-37. doi: 10.1016/j.ymeth.2018.10.001.
4.Xinyu Zhang, Lei Han, Huifang Zong, Kai Ding, Yuan Yuan, Jingyi Bai, Yuexian Zhou, Baohong Zhang*, Jianwei Zhu*. Enhanced production of anti-PD1 antibody in CHO cells through transient co-transfection with anti-apoptotic genes Bcl-xL and Mcl-1. Bioprocess and Biosystems Engineering. 2018, 41:633–640.
5.Zhao J, Zhang B, Zhu J, Nussinov R, Ma B. Structure and energetic basis of overrepresented light chain in systemic light chain amyloidosis patients. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2018, 1864:2294-2303.
6.Lei Han, Junsheng Chen, Kai Ding, Huifang Zong, Yueqing Xie, Hua Jiang, Baohong Zhang, Huili Lu, Weihan Yin, John Gilly, Jianwei Zhu. Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system. Scientific Reports. 2017, 7(1):8360.
7.H Guo, Q Zhu, X Yu, S B Merugu, H B Mangukiya, N Smith, Z Li, B Zhang, H Negi, R Rong, K Cheng, Z Wu, D Li. Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization. Oncogene. 2017, 36(36):5098-5109.
8.Huifang Zong, Lei Han, Kai Ding, Jiaxian Wang, Tao Sun, Xinyu Zhang, Cedric Cagliero, Hua Jiang, Yueqing Xie, Jianrong Xu, Baohong Zhang*, JianweiZhu. Producing defucosylated antibodies with enhanced in vitro ADCC via FUT8 knockout CHO-S. Engineering in Life Sciences. 2017, 17(7):801–808.
9.Kai Ding, Lei Han, Huifang Zong, Junsheng Chen, Baohong Zhang*, Jianwei Zhu*. Production process reproducibility and product quality consistency of transient gene expression in HEK293 cells with anti-PD1 antibody as the model protein. Applied Microbiology and Biotechnology. 2017, 101(5):1889–1898.
10.Sun T, Li C, Han L, Jiang H, Xie Y, Zhang B, Qian X, Lu H, Zhu J. Functional knockout of FUT8 in Chinese hamster ovary cells using CRISPR/Cas9 to produce a defucosylated antibody. Engineering in life sciences. 2015, 15(6): 660–666.
11.Sang Y, Xie K, Mu Y, Lei Y, Zhang B, Xiong S, Chen Y, Qi N. Salt ions and related parameters affect PEI-DNA particle size and transfection efficiency in Chinese hamster ovary cells. Cytotechnology. 2015;67(1):67-74.


先后主持参与各级课题20余项，发表SCI论文近20篇，申请专利18项，其中国际专利3项。荣获2018 年中国产学研合作创新成果优秀奖（排名第二）。