张岩 副教授

电话：
邮箱：zhangyan_sjtu@sjtu.edu.cn



个人简历 研究方向 发表论文 科研成果
1996年9月－2000年7月：本科，化学，南开大学
2000年9月－2005年11月：硕博连读，分析化学，中科院大连化学物理研究所(导师：梁鑫淼研究员)
2005年11月－2007年5月：助理研究员、中科院大连化学物理研究所
2007年6月－2010年6月：Postdoctoral Scholar、美国加州大学欧文分校
2010年7月－2012年6月：Assistant Specialist、美国加州大学欧文分校
2012年7月－2013年12月：Associate Specialist、美国加州大学欧文分校
2015年1月－至今：副教授、上海交通大学药学院


研究方向:
(1) G蛋白偶联受体和信号转导研究；
(2) 基于受体和信号转导的天然产物药物筛选；
(3) 免疫抗炎活性天然产物的发现及机制研究。

代表性论文（#第一作者，*通讯作者）
1.Dong L, Zhang B, Wu L, Shang Z, Liu S, Jiang X, Wang H, Fan L, Zhang Y*, Xiao H*. Proteomics Analysis of Cellular BRS3 Receptor Activation Reveals Potential Mechanism for Signal Transduction and Cell Proliferation. Journal Proteome Research. 2020, 19, 1513-1521.
2.Qiao Z #, Zhang Y #, Ge M #, Liu S, Jiang X, Shang Z, Liu H, Cao C, Xiao H. Cancer Cell Derived Small Extracellular Vesicles Contribute to Recipient Cell Metastasis Through Promoting HGF/c-Met Pathway. Molecular & Cellular Proteomics. 2019, 18(8):1619-1629.
3.Wang L, Zhang Y, Wang C, Zhang X, Wang Z, Liang X, Alachkar A, Civelli O. A Natural Product With High Affinity to Sigma and 5-HT 7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia. Neurochemical Research. 2019, 44(11):2536-2545.
4.Zhang W, Yan J, Wu L, Yu Y, Ye RD, Zhang Y*, Liang X*. In vitro immunomodulatory effects of human milk oligosaccharides on murine macrophage RAW264.7 cells. Carbohydrate Polymers. 2018, 207: 230-238
5.Wang Z, Cai J, Fu Q, Cheng L, Wu L, Zhang W, Zhang Y*, Jin Y*, Zhang C*. Anti-inflammatory activites of compounds isolated from the Rhizome of Anemarrhena asphodeloides. Molecules. 2018, 23(10). pii: E2631.
6.Wu L, Zhang W, Qiu X, Wang C, Liu Y, Wang Z, Yu Y, Ye RD, Zhang Y*. Identification of alkaloids from Corydalis yanhusuo W.T. Wang as dopamine D1 receptor antagonists by using CRE-luciferase reporter gene assay. Molecules. 2018, 23(10). pii: E2585.
7.Xie Y, Zhang W, Zhu S, Cheng T, Wu G, Muhammad I, Yan S, Zhang Y*, Jin H*, Zhang W*. Xyloplains A-F, six new guaiane-type sesquiterpenoid dimers from Xylopia vielana. RSC Advance. 2018, 8, 25719-25724.
8.Zhang Y#, Liu Y#, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O. Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3. The FASEB Journal. 2018, 32(6):3184-3192.
9.Fan C, Wu LH, Zhang GF, Xu F, Zhang S, Zhang X, Sun L, Yu Y, Zhang Y*, Ye RD*.4'-Hydroxywogonin suppresses lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages and acute lung injury mice. PLoS One. 2017, 12(8): e**.
10.Fan C, Jin HZ, Wu L, Zhang Y, Ye RD, Zhang W, Zhang Y*. An exploration of traditional Chinese medicinal plants with ani-inflammatory activities. Evidence Based Complementary and Alternative Medicine. 2017: **.
11.Wu LH, Fan YP, Fan C, Yu Y, Sun L, Jin Y*, Zhang Y*, Ye RD*. Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages. European Journal of Pharmacology. 2017, 801:46-53.
12.Zhang Y, Zhao XC, Xie YG, Fan C, Huang YY, Yan SK, Zhang Y *, Jin HZ *, Zhang WD*. Eight new γ-lactam alkaloids from the roots of the Hemerocallis minor mill. Fitoterapia. 2017, 118: 80-86.
13.Li SQ, Sun N, Gong P, Zhang HB, Liu J, Wang D, Sun YP, Zhang Y, Qian F, Zhao B, Yu Y, Ye RD. The expression of forml peptide receptor 1 is correlated with tumor invasion of human colorectal cancer. Scientific Reports, 2017, 7(1): 5918.
14.Ren J, Fan C, Guo YG., Yan SK., Ye RD., Zhang Y*, Jin HZ*, Zhang WD*. New biphenantherene and nervogenic acid derivatives from Liparis regnieri Finet and their inhibitory activities against NF-κB activation. Tetrahedron. 2017, 73 (12), 1611–1617
15.Sun Y, Liu S, Qiao Z, Shang Z, Xia ZJ, Niu XM, Qian LQ, Zhang Y, Fan LY, Cao CX, Xiao H*. Systematic comparison of exosomal proteomes from human saliva and serum for the detection of lung cancer, Analytica Chimica Acta. 2017, 982:84-95.
16.Pan YP#, Zhang Y#, Fan C, Zhang Y, Yan SK, Jin HZ, Zhang WD. Ligans from the whole plants of hedyotis uncinella. Natural Product Communications. 11 (0): 1-2. (Co-first author)
17.Wang L, Zhang Y, Wang Z, Gong N, Kweon TD, Vo B, Wang C, Zhang X, Chung JY, Alachkar A., Liang X., Lu DZ., Civelli O. The Antinociceptive Properties of the Corydalis yanhusuo Extract. PLoS One. 2016, 11(9): e**.
18.Xiao H, Zhang Y, Kim Y, Kim S, Kim JJ, Kim KM, Yoshizawa J, Fan LY, Cao CX., Wong DT. Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. Scientific Report. 2016, 6: 22165.
19.Zhang Y*, Long Z, Guo Z, Wang Z, Zhang X, Y, RD, Liang X, Civelli O. Hydroxycinnamic acid amides from Scopolia tangutica inhibit the activity of M1 muscarinic acetylcholine receptor in vitro. Fitoterapia. 2016, 108, 9-12.
20.Xiao H, Langerman A, Zhang Y, Khalid O, Hu S, Cao CX, Lingen MW, Wong DT. Quantitative proteomic analysis of microdissected oral epithelium for cancer biomarker discovery. Oral Oncology. 2015, 51, 1011-1019.
21.Zhang Y#, Wang C#, Guo Z, Zhang X, Wang Z, Liang X, Civelli O. Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography. Journal of Ethnopharmacology. 2014, 155, 1597-1602.
22.Long Z#, Zhang Y#, Guo Z, Wang L, Xue X, Zhang X, Wang S, Wang Z., Civelli O, Liang X. Amide alkaloids from Scopolia tangutica. Planta Medica. 2014, 80, 1124-1130.
23.Zhang Y#, Wang CR#, Wang LE, Parks GS, Zhang XL, Guo ZM, Ke YX, Li KW, Kim MK, Vo B, Borrelli E, Ge GB, Yang L, Wang ZW, Garcia-Fuster MJ, Luo ZD, Liang XM, Civelli O. A novel analgesic isolated from a Traditional Chinese medicine. Current Biology. 2014, 24 (2):117-123.
24.Civelli O, Reinscheid RK, Zhang Y, Wang Z, Fredriksson R, Schi?th HB. G protein-coupled receptor deorphanizations. Annual Review of Pharmacology and Toxicology. 2013, 53, 127-146.
25.Zhang Y#, Xu J#, Wang Z, Zhang X, Liang X, Civelli O. BmK-YA, an enkephalin-like peptide in scorpion venom. PLos One. 2012, 7(7), e40417.
26.Zhang Y#, Wang ZW#, Cox D.P, Civelli O. Study on the activation of the opioid receptors by a set of morphine derivatives in a well-defined assay system. Neurochemical Research. 2012, 37(7), 410-416.
27.Zhang Y, Wang Z.W, Parks G.S, Civelli O. Novel neuropeptides as ligands of orphan G protein-coupled receptors. Current Pharmaceutical Design. 2011, 17, 2626-2631.
28.Sun Y, Zhang X, Xue X, Zhang Y, Xiao H, Liang X. Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS. Journal of Chromatographic Science. 2009, 47(3):190-196.
29.Zhang C.N, Wang X.M, Zhang X.Z, Zhang Y, Xiao H.B, Liang X.M. Bioassay-guided separation of citreorosein and other oestrogenic compounds from Polygonum cuspidatum. Phytotherapy Research. 2009, 23(5):740-741.
30.Zhang C.N, Zhang X.Z, Zhang Y, Xu Q, Xiao H.B, Liang X.M. Analysis of estrogenic compounds in Polygonum cuspidatum by bioassay and high performance liquid chromatography. Journal of Ethnopharmacology. 2006,105: 223-228.
31.Zhang Y, Chen J.P, Zhang C.Z, Wu W.Z, Liang X.M. Analysis of the estrogenic components in kudzu root by bioassay and high performance liquid chromatography. The Journal of Steroid Biochemistry and Molecular Biology. 2005, 94: 375-381.
32.Zhang Y, Xu Q, Zhang X.Z, Chen J.P, Liang X.M, Kettrup A. Identification of isoflavones and description of the biotransformation of kudzu root by high-performance liquid chromatography-tandem mass spectrometry. Analytical & Bioanalytical Chemistry. 2005, 383 (5), 787-796.
33.Zhang C.Z, Wang S.X, Zhang Y, Chen J.P, Liang X.M. In vitro estrogenic activities of Chinese medicinal plants traditionally used for the management of menopausal symptoms. Journal of Ethnopharmacology. 2005, 98: 295-300.
授权专利
1.梁鑫淼，许俊彦，张岩，张秀莉，王志伟，奥利维尔.奇韦利。GPCR活性多肽及其提取分离和应用，中国，3.4，授权日2014-09-17
2.梁鑫淼，王超然，张秀莉，张岩，王志伟，奥利维尔.奇韦利，柯燕雄，王藜恩。小檗碱类化合物的用途和制备方法，中国，2.9，授权日2016-08-10
3.Xinmiao Liang, Chaoran Wang, Xiuli Zhang, Yan Zhang, Zhiwei Wang, Olivier Civelli, Lien Wang. Use and preparation method of berberine compounds, 美国发明专利， US**B2, 授权日2017-04-04


张岩，2007年到2013年，在美国加州大学欧文分校药理系进行博士后研究，合作导师为GPCR领域的著名科学家Olivier Civelli教授。2015年加入上海交通大学药学院。先后在Current Biology, FASEB Journal, European Journal of Pharmacology, Carbohydrate Polymers，Journal Proteome Research等国际重要学术期刊发表论文30余篇，其中第一或共同通讯作者20余篇；授权中国发明专利2项、美国专利1项；主持国家自然科学基金一项，上海市自然科学基金面上项目一项。