上海交通大学医学院研究生导师简介盛祖杭

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上海交通大学免费考研网/2013-01-09

基本信息

导师姓名:	盛祖杭	专业代码:	071006
性别:	男	专业名称:	神经生物学
培养单位:	基础医学院	三级学科/ 专业领域:	未设
导师类型:	博士生导师	专业学位导师:
联系方式:	ShengZ@ninds.nih.gov Lab Homepage: http://neuroscience.nih.gov/lab.asp?org_id=56

研究方向 (点击浏览详细信息)

Mechanisms of organelle transport along axon and their impact on neurodegenerative diseases.

社会任职

Senior Principal Investigator (with tenure), Chief of Synaptic Functions Section, NINDS, NIH

Member of American Society for Neuroscience

Member of American Society for Cell Biology

Member of American Society for Biochemistry and Molecular Biology

Editorial Board of The Journal of Biological Chemistry

Editorial Board of Faculty 1000

NINDS/NIDCD Animal Care and Use Committee

Howard Hughes Medical Institute (HHMI)-NIH Research Program Advisory Committee

NIH Earl Stadtman Neuroscience Tenure-track Investigator Search Committee

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
1ZIANS003029-06	Mitochondrial Transport: Impact on Synaptic Transmission and Neurodegeneration	The Intramural Research Program of NIH	2012-01~~2012-12	US$121万元	课题负责人
1ZIANS002946-16	Axonal Transport Regulates synaptic function and axonal homeostasis	The Intramural Research Program of NIH	2012-01~~2012-12	US$148万元	课题负责人
1ZIANS003029-05	Mitochondrial Transport: Impact on Synaptic Transmission and Neurodegeneration	The Intramural Research Program of NIH	2011-01~~2011-12	US$130万元	课题负责人
1ZIANS002946-15	Axonal Transport Regulates Neurotransmission and Autophagy-Lysosomal Function	The Intramural Research Program of NIH	2011-01~~2011-12	US$152万元	课题负责人
1ZIANS003029-04	Regulation of Mitochondrial Transport and its Impact on Synaptic Transmission	The Intramural Research Program of NIH	2010-01~~2010-12	US$110万元	课题负责人
1ZIANS002946-14	Regulation of Synaptic Transmission and Autophagy-Lysosomal Function	The Intramural Research Program of NIH	2010-01~~2010-12	US$110万元	课题负责人

学术论文 (#为通讯作者,*为共同第一作者)

1、Qian Cai, Hesham Mostafa Zakaria, Anthony Simone, and Zu-Hang Sheng#. Spatial Parkin Translocation and Degradation of Depolarized Mitochondria via Mitophagy in Live Cortical Neurons.. Current Biology (IF=9.647),2012;22:545-552
2、Zu-Hang Sheng#,Qian Cai. Mitochondrial Transport in Neurons: Impact on Synaptic Homeostasis and Neurodegeneration.. Nature Reviews Neuroscience (IF=30.445),2012;13:77-93
3、Bing Zhou, Qian Cai, Yuxiang Xie, and Zu-Hang Sheng#. Snapin recruits dynein to BDNF-TrkB signaling endosomes for retrograde axonal transport and is essential for dendrite growth of cortical neurons. Cell Reports,2012;2:42-51
4、Qian Cai, Hesham Mostafa Zakaria, Zu-Hang Sheng#. Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons. Autophagy (IF=7.453),2012;8(6):976-978
5、Qian Cai and Zu-Hang Sheng. Uncovering the role of Snapin in regulating autophagy-lysosomal function. Autophagy (IF=7.453),2011;7:445-447
6、Yi-Bing Zhu, Zu-Hang Sheng#. Increased Axonal Mitochondrial Mobility Does Not Slow ALS-like Disease in Mutant SOD1 Mice.. The Journal of Biological Chemistry (IF=4.773),2011;286:23432-23440
7、Bing Zhou, Yi-Bing Zhu, Lin Lin, Qian Cai, and Zu-Hang Sheng #. Snapin deficiency is associated with developmental defects of the central nervous system. Bioscience Reports,2011;31:151-158
8、Qian Cai, Matthew L. Davis, and Zu-Hang Sheng#. Regulation of Axonal Mitochondrial Transport and Its Impact on Synaptic Transmission. Neurosci Res,2011;70(1):9–15
9、Qian Cai, Li Lu, Jin-Hua Tian, Yi-Bing Zhu, Haifa Qiao, and Zu-Hang Sheng#. Snapin-regulated late endosomal transport is critical for efficient autophagy-lysosomal function in neurons. Neuron (IF=14.736),2010;68:73-86
10、Yan-Min Chen, Claudia Gerwin, and Zu-Hang Sheng#. Dynein Light Chain LC8 Regulates Syntaphilin-Mediated Mitochondrial Docking in Axons. Journal of Neuroscience (IF=7.27),2009; 29:9429-9438
11、Ping-Yue Pan, Jin-Hua Tian, Zu-Hang Sheng#. Snapin facilitates the synchronization of synaptic vesicle fusion. Neuron (IF=14.736),2009;61:412-424
12、Cai Qian, Zu-Hang Sheng#. Mitochondrial transport and docking in axons. Exp Neurol,2009;218(2):257-67
13、Jian-Sheng Kang, Jin-Hua Tian*, Ping-Yue Pan*, Philip Zald, Cuiling Li, Chuxia Deng, and Zu-Hang Sheng#. Docking of Axonal Mitochondria by Syntaphilin Controls their Mobility and Affects Short-term Facilitation. Cell (IF=32.403),2008;132:137-248
14、Qian Cai, Ping-Yue Pan, and Zu-Hang Sheng#. Syntabulin-kinesin-1 family 5B-mediated axonal transport contributes to activity-dependent presynaptic assembly. Journal of Neuroscience (IF=7.27),2007;27:7284-7296
15、Jin-Hua Tian, Zheng-Xing Wu, Michael Unzicker, Li Lu, Qian Cai, Cuiling Li, Claudia Schirra, Ulf Matti, David Stevens, Chuxia Deng, Jens Rettig, and Zu-Hang Sheng#. The role of snapin in neurosecretion: snapin knockout mice exhibit impaired calcium-dependent exocytosis of large dense-core vesicles in chromaffin cells. Journal of Neuroscience (IF=7.27),2005;25:10546-10555