上海交通大学医学院研究生导师简介方超

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上海交通大学免费考研网/2013-01-09

基本信息

导师姓名:	方超	专业代码:	100706
性别:	男	专业名称:	药理学
培养单位:	基础医学院	三级学科/ 专业领域:	未设
导师类型:	硕士生导师	专业学位导师:
联系方式:	fangchao_china@yahoo.com.cn 上海市重庆南路280号3号楼305室（200025）021-63846590-778013

研究方向 (点击浏览详细信息)

肿瘤靶向治疗纳米递释系统关键技术

具有抗血管生成活性的天然产物和先导化合物的高内涵筛选及化学生物学研究

肿瘤靶向基因治疗

社会任职

中国药学会会员

上海市药学会会员

上海市药理学会会员

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
81272569	K237-KDR介导隐形纳米粒“节拍式化疗”诱导肿瘤血管“正常化”的作用和机制研究	国家自然科学基金	2013-01~~2016-12	70万元	课题负责人
12PJD023	靶向纳米给药系统“节拍式化疗”调控乳腺肿瘤血管“正常化”的研究	上海市科委浦江人才	2012-10~~2014-09	20万元	课题负责人
09QA1403500	肿瘤血管靶向隐形纳米粒抗血管生成逆转肿瘤多药耐药的研究	上海市科委启明星	2009-07~~2011-06	15万元	课题负责人
2010CB529806	重要药用前景动物多肽毒素的临床应用基础研究	国家重点基础研究（973计划子项目）	2009-01~~2014-12	247万元	课题参与人
30873179	SP5.2-Flt-1介导隐形纳米粒主动靶向肿瘤血管的"节拍式化疗"研究	国家自然科学基金	2009-01~~2011-12	25万元	课题负责人
30600788	载Kringle 5基因的主动靶向肿瘤新生血管内皮细胞APN受体的隐形纳米粒的研究	国家自然科学基金	2007-01~~2009-12	20万元	课题负责人

学术论文 (#为通讯作者,*为共同第一作者)

1、Wang QW, Yu DH, Lin MG, Zhao M, Zhu WJ, Lu Q, Li GX, Wang C, Yang YF, Qin XM, Fang C#, Chen HZ, Yang GH. Antiangiogenic polyketides from Peperomia dindygulensis Miq. Molecules,2012;17(4):4474-83.
2、Xie J, Wang BS, Yu DH, Lu Q, Ma J, Qi H, Fang C#, Chen HZ. Dichloroacetate shifts the metabolism from glycolysis to glucose oxidation and exhibits synergistic growth inhibition with cisplatin in HeLa cells. Int J Oncol,2011;38(2):409-417.
3、Lin MG, Yu DH, Wang QW, Lu Q, Zhu WJ, Bai F, Li GX, Wang XW, Yang YF, Qin XM, Fang C#, Chen HZ, Yang GH. Secolignans with antiangiogenic activities from Peperomia dindygulensis. Chem Biodivers,2011;8(5):862-871.
4、Yu DH, Lu Q, Xie J, Fang C#, Chen HZ. Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculature. Biomaterials,2010;31(8):2278-2292.
5、Hong M, Zhu S, Jiang Y, Tang G, Sun C, Fang C, Shi B, Pei Y. Novel anti-tumor strategy: PEG-hydroxycamptothecin conjugate loaded transferrin-PEG- nanoparticles. J Control Release,2010;141(1):22-29.
6、Liu F, Fang C(co-first author)*, Ye X, Lu Q, Yu DH, Zhang WW, Qi H, Xie J, Lieber A, Chen HZ . Anti-4-1BB scFv immunogene therapy and low dose cyclophosphamide exhibit a synergistic antitumor effect in established murine lung tumors. Cancer Biol Ther,2009;8(8):707-713
7、Lu Q, Yu DH, Fang C, Liu F, Ye X, Zhao Y, Qin J, Guo XK, Liang M, Hu F, Chen HZ. Influence of E3 region on conditionally replicative adenovirus mediated cytotoxicity in hepatocellular carcinoma cells. Cancer Biol Ther,2009;8(12):1125-1132.
8、Fu J, Fang C (co-first author)*, Cui YY, Yang LM, Zhu L, Feng XM, Zheng PL, Lu Y, Chen HZ. Quantitative determination of a novel enantiomeric tropane analogue, (-)-satropane, in biological fluids using liquid chromatography/tandem mass spectrometry. Biomed Chromatogr,2009;23(10):1044-1050.
9、Fang C, Liu Y, Ye X, Rong ZX, Feng XM, Jiang CB, Chen HZ. Synergistically enhanced transdermal permeation and topical analgesia of tetracaine gel containing menthol and ethanol in experimental and clinical studies. Eur J Pharm Biopharm,2008;68(3):735-740.
10、Liu F, Lu Q, Ye X, Fang C, Zhao Y, Liang M, Hu F, Lieber A, Chen HZ. Cancer gene therapy of adenovirus-mediated anti-4-1BB scFv in immunocompetent mice. Cancer Biol Ther,2008;7(3):448-453.
11、Feng XM, Ren Q, Zhang WZ, Shen HF, Rong ZX, Fang C, Chen HZ. Preparation and evaluation of a novel delayed-onset sustained-release system of propranolol hydrochloride. J Pharm Pharmacol,2008;60(7):817-822.
12、Ren Z, Ye X, Fang C, Lu Q, Zhao Y, Liu F, Liang M, Hu F, Chen HZ. Intratumor injection of oncolytic adenovirus expressing HSP70 prolonged survival in melanoma B16 bearing mice by enhanced immune response. Cancer Biol Ther,2007;7(2):191-195.
13、Jiang Y, Tang G, Hong M, Zhu S, Fang C, Shi B, Pei Y. Active tumor-targeted delivery of PEG-protein via transferrin-transferrin-receptor system. J Drug Target,2007;15(10):672- 683.
14、Fang C, Shi B, Pei YY, Hong MH, Wu J, Chen HZ. In vivo tumor targeting of tumor necrosis factor-α-loaded stealth nanoparticles: Effect of MePEG molecular weight and particle size. Eur J Pharm Sci,2006;27(1):27-36.
15、Shi B, Fang C, Pei YY. Stealth PEG-PHDCA niosomes: Effects of chain length of PEG and particle size on niosomes surface properties, in vitro drug release, phagocytic uptake, in vivo pharmacokinetics and antitumor activity. J Pharm Sci,2006;95(9):1873-1887.
16、Fang C, Shi B, Pei YY. Effect of PEG molecular weight and particle size on in vitro release of tumor necrosis factor-α-loaded nanoparticles. Acta Pharmacol Sin,2005; 26(2):242-249.
17、Shi B, Fang C, You MX, Zhang Y, Fu SK, Pei YY . Stealth MePEG-PCL micelles: Effects of polymer composition on micelle physicochemical characteristics, in vitro drug release, in vivo pharmacokinetics in rats and biodistribution in S180 mice. Colloid Polym Sci,2005;283(9):954-967.
18、Liu Y, Ye X, Feng XM, Zhou GH, Rong ZX, Fang C, Chen HZ. Menthol facilitates the skin analgesic effect of tetracaine gel. Int J Pharm,2005;305(1-2):31-36.