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上海交通大学医学院研究生导师简介 朱亮

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 朱亮 专业代码: 100706
性别: 专业名称: 药理学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 硕士生导师 专业学位导师:
联系方式: zhuliang17@hotmail.com 上海市重庆南路280号3号楼 Tel: 021-54561256
研究方向 (点击浏览详细信息)
受体药物新靶点确认及高内涵分析
内、外源性小分子的干细胞外信号调控及其成药性研究
社会任职
上海市药理学会理事、副秘书长
上海研发公共服务平台专家
国家医学考试专家委员会委员
药理学科实验室主任、大型仪器/核心设施平台主任
上海高校转化医学协同创新中心办公室主任、核心支撑平台主任
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
12ZR1415700恶性畸胎瘤干细胞非神经源性谷氨酸递质信号系统及其自分泌环路机制上海市自然科学基金2012-07~~2015-0610万元课题负责人
2011DFA33180AMPA受体和M1受体协同调控机制及靶标药物研究国家国际合作专项2012-01~~2014-12179万元课题参与人
S30201NSC分化过程经典递质动态轮廓分析上海市重点学科开放课题2011-05~~2013-0510万元课题负责人
2009ZX09301-007综合性新药研究技术开发大平台国家“新药创制”科技重大专项2010-09~~2012-0315万元子课题负责人
2009ZX09103-077具有多靶点作用抗老年性痴呆候选药物XQ509的研究国家“新药创制”科技重大专项2009-06~~2011-06150万元课题参与人
30701018异位增强M1受体信号偶联效率及其别构作用机制国家自然基金委,面上项目2008-01~~2010-1216万元课题负责人
06BZ012别构调节胆碱M1受体在阿尔茨海默病体外模型的效应及机制上海市教委,发展基金2007-01~~2008-126万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Yumei Cheng, Yongzhen Liu, Hao Wang, Juan Li, Jin Ren, Liang Zhu#, Likun Gong. 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats. J Ethnopharmacol,2013;145(1):85-93
2、Xu ZP, Devillier P, Xu GN, Zhu L, Zhou W, Hou LN, Tang YB, Yang K, Yu ZH, Chen HZ, Cui YY. TNF-α-induced CXCL8 production by A549 cells: Involvement of the non-neuronal cholinergic system. Pharmacol Res,2012;68(1):16-23
3、TANG Ya-Bin, TENG Lin, SUN Fan, WANG Xiao-Lin, PENG Liang, Cui Yong-Yao, HU Jin-Jia, LUAN Xin, ZHU Liang#, CHEN Hong-Zhuan. Determination of glycine in biofluid by hydrophilic interaction chromatography coupled with tandem mass spectrometry and its application to the quantification of glycine released by embryonal carcinoma stem cells. J Chromatogr B,2012;15:61-6
4、Xu GN, Yang K, Xu ZP, Zhu L, Hou LN, Qi H, Chen HZ and Cui YY. Protective effects of anisodamine on cigarette smoke extract-induced airway smooth muscle cell proliferation and tracheal contractility. Toxicol Appl Pharmacol,2012;262(1):70-79
5、Xu Z.P., Yang K., Xu G.N., Zhu L., Hou L.N., Zhang W.H., Chen H.Z. and Cui, Y.Y. Role of M3 mAChR in in vivo and in vitro models of LPS-induced inflammatory response. Int Immunopharmacol,2012;14(3):320-7
6、Gao X, Yao L, Song Q, Zhu L, Xia Z, Xia H, Jiang X, Chen J, Chen H. The association of autophagy with polyethylenimine-induced cytotoxicity in nephritic and hepatic cell lines. Biomaterials,2011;32(33):8613-25
7、Xu ZP, Wang H, Hou LN, Xia Z, Zhu L, Chen HZ, Cui YY. Modulatory effect of anisodamine on airway hyper-reactivity and eosinophilic inflammation in a murine model of allergic asthma. Int Immunopharmacol,2011;11(2):260-5
8、Zheng J, Feng X, Hou L, Cui Y, Zhu L, Ma J, Xia Z, Zhou W, Chen H. Latanoprost Promotes Neurite Outgrowth in Differentiated RGC-5 Cells via the PI3K-Akt-mTOR Signaling Pathway. Cell Mol Neurobiol,2011;31(4):597-604
9、Zhu X, Zhou W, Cui Y, Zhu L, Li J, Feng X, Shao B, Qi H, Zheng J, Wang H, Chen H.. Pilocarpine protects cobalt chloride-induced apoptosis of RGC-5 cells: involvement of muscarinic receptors and HIF-1 alpha pathway. Cell Mol Neurobiol,2010;30(3):427-35
10、Cui Y, Devillier P, Kuang X, Wang H, Zhu L, Xu Z, Xia Z, Zemoura L, Advenier C, Chen H.. Tiotropium reduces lung inflammation in a model of chronic gastro-oesophageal reflux.. Eur Respir J.,2010;35(6):1370-6
11、Song MK, Cui YY, Zhang WW, Zhu L, Lu Y, Chen H Z.. The facilitating effect of systemic administration of Kv7/M channel blocker XE991 on LTP induction in the hippocampal CA1 area independent of muscarinic activation.. Neurosci Lett,2010;461(1):25-9.
12、Zhu X, Zhou W, Cui Y, Zhu L, Li J, Xia Z, Shao B, Wang H, Chen H.. Muscarinic activation attenuates abnormal processing of beta-amyloid precursor protein induced by cobalt chloride-mimetic hypoxia in retinal ganglion cells.. Biochem Biophys Res Commun.?,2009;384(1):110-3.
13、Niu YY, Zhu L*, Cui YY, Liu HZ, Chen HZ, Lu Y.. The absolute configuration plays an important role in muscarinic activity of BGT-A and its analogs.?. Bioorg Med Chem?2008?,2008;16(24):10251-6.
14、Zhang WW, Song MK, Cui YY, Wang H, Zhu L, Niu YY, Yang LM, Lu Y, Chen HZ.. Differential neuropsychopharmacological influences of naturally occurring tropane alkaloids anisodamine versus scopolamine.. Neurosci Lett.,2008;443(3):241-5
15、Cui YY, Zhu L, Wang H, Advenier C, Chen HZ and Devillier P.. Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.. Life Sci,2008;82:949-955.
16、Wei Zhou, Xu Zhu, Liang Zhu, Yongyao Cui, Hao Wang, Hong Qi, Qiushi Ren, Hongzhuan Chen.. Neuroprotection of muscarinic receptor agonist pilocarpine against glutamate-induced apoptosis in retinal neurons.. Cell Mol Neurobiol,2008;28(2):263-75
17、Zhu L, Yang LM, Cui YY, Zheng PL, Niu YY, Wang H, Lu Y, Ren QS, Wei PJ and Chen HZ.. Stereoselectivity of satropane, a novel tropane analogue, on iris muscarinic receptor activation and intraocular hypotension.. Acta Pharmacol Sin,2008;29(2):177-184
18、Li J, Shao B, Zhu, L, Cui Y, Dong C, Miezan Ezoulin J M, Gao X, Ren Q, Heymans F, Chen H.. PMS777, A Bis-interacting Ligand for PAF Receptor Antagonism and AChE Inhibition, Attenuates PAF-induced Neurocytotoxicity in SH-SY5Y Cells. . Cell Mol Neurobiol.,2008;28:125-136
19、Niu YY, Yang LM, Deng KM, Yao JH, Zhu L, Chen CY, Zhang M, Zhou JE,?Shen TX, Chen HZ and Lu Y.. Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists.. Bioorg Med Chem Lett. 2007,2007;17(8):2260-6
20、Zhu L, Cui YY, Feng JM, Wu XJ, Chen HZ.. Aceclidine and pilocarpine interact differently with muscarinic receptor in isolated rabbit iris muscle.. Life Sci.,2006;78(14):1617-32


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