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上海交通大学医学院研究生导师简介 易静

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 易静 专业代码: 071009
性别: 专业名称: 细胞生物学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: yijing@shsmu.edu.cn 重庆南路280号7号楼109室,电话63846590转776565,邮编200025
研究方向 (点击浏览详细信息)
活性氧相关的细胞信号转导和蛋白质修饰
社会任职
中国细胞生物学会资深理事
中国细胞生物学会医学细胞生物学分会副会长
中国细胞生物学会教学和普及分会会长
中华医学会医学细胞生物学分会常务理事
细胞生物学学报编委
Oxidative Medicine and Cellular Longevity杂志编委
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
11JC1406900SENP3在氧化应激诱导上皮间质转化中的作用及其对胃炎相关胃癌的影响市科委基础研究重点项目(连续支持)2011-12~~-2014-1230万元课题负责人
91013012以紫草素衍生物/低氧诱导因子-1为模型,探讨抗癌醌类化合物结构与靶向作用特异性和活性氧效应普遍性的关系国家自然科学基金重大研究计划培育项目2011-01~~-2013-1250万元课题负责人
0810410704000利用以脂质体模拟线粒体的无细胞系统进行靶向Bcl-2蛋白的抗癌化合物筛选和机制研究市科委国际合作项目2010-04~~2012-0315万元课题负责人
C0701核仁蛋白质SENP3应答细胞氧化应激信号的机制国家自然基金,面上项目2010-01~~2012-1235万元课题负责人
08JC1413800植物小分子化合物靶向抑制HIF-1治疗非雄激素依赖的前列腺癌的机制和应用研究市科委基础研究重点项目2008-10~~2010-0930万元课题负责人
30570965活性氧通过低氧诱导因子-1的化学修饰影响肿瘤细胞耐药性的机制国家自然基金委,面上项目2006-01~~2008-1228万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Wang Y, Yang J, Yi J. #. Redox sensing by proteins: oxidative modifications on cysteines and the consequent events. . Antioxid Redox Signal.,2012;16 (7):649-657
2、Wang Y, Yang J, Yang K, Cang H, Huang XZ, Li H, Yi J. The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress. . Acta Pharmacol Sin.,2012;33(7):953-963
3、Sang J, Yang K, Sun Y, Han Y, Cang H, Chen Y, Shi G, Wang K, Zhou J, Wang X, Yi J. #. SUMO2 and SUMO3 transcription is differentially regulated by oxidative stress in an Sp1-dependent manner. . Biochem J.,2011;435(2):489-498.
4、Han Y, Huang C, Xiang B, Sun Y, Yeh ET, Chen Y, Hu Q, Wang J, Gao F, Yi J. #. SENP3-mediated de-conjugation of SUMO2/3 from PML is correlated with accelerated cell proliferation under mild oxidative stress.. J Biol Chem,2010;285(17):12906-15
5、Yan S, Sun X, Xiang B, Cang C, Kang X, Chen Y, Li H, Shi G, Yeh ETH, Wang B, Wang X Yi J, #. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.. The EMBO Journal.,2010;29(22):3773-3786
6、Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Cang H, Yi J. #. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with Apaf-1. Cell Research,2009;19(4):449-457
7、Wang R, Zou Y, Yuan Z, Wang Y, Chen Y, Mao Y, Zhu Z, Li H, Tang X, Lu J, Yi J#, . Autografts and xenografts of the skin fibroblasts delivering BMP-2 effectively promote orthotopic and ectopic osteogenesis.. The Anatomical Record,,2009;292 (6):778-786
8、Huang C, Han Y, Wang Y, Yan S, Sun XX, Yeh ET, Chen Y, Cang H, Li H, Cheng J, Tang XM, Yi J. #. SUMO-specific protease 3 is responsible for HIF-1 transactivation under mild oxidative stress via P300 de-SUMOylation.. EMBO J,2009;28(18):2748-2762
9、Cai J, Niu X, Chen Y, Hu Q, Shi G, Wu H, Wang J, Yi J.#. Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis. Neoplasia,2008;10(1):41-51
10、Wang J, Li L, Cang H, Shi G, Yi J. #. NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells.. Leuk Res.,2008;32(3): 429-436
11、Huang XZ, Wang J, Huang C, Chen Y, Shi G, Hu Q Yi J.. Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1.. Cancer Biol Ther.,2008;7(3):468-475
12、Li L., Wang J., Ye RD, Shi G. Jin H., Tang X.,Yi J. . PML/RARa fusion protein mediates the unique sensitivity to arsenic cytotoxicity in acute promyelocytic leukemia cells: . Journal of Cellular Physiology.,2008;217(2):486-493
13、Wang J., Yi J.#. Cancer cell killing via ROS: To increase or decrease, that is a question . Cancer Biol Ther.,2008;7(12):1875-1884
14、Wang YM. Huang XZ. Cang H. Gao F. Ozaki T. Yamamoto T. Yi J. The endogenous reactive oxygen species promote NF-κB activation by targeting on activation of NF-κB-inducing kinase in oral squamous carcinoma cells.. Free Radic Res.,2007;41(9):963-71
15、Jing Y, Yang J, Wang Y, Li H, Chen Y, Hu Q, Shi G, Tang X, Yi J#. Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin. Free Radic Biol Med.,2006;40(12):2183-97
16、Yi#, J.; Yang, J.; He, R.; Gao, F.; Sang, H.R.; Tang, X.M.; Ye, R.D. Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling. Cancer Research,2004;64(1):108-116
17、Yang J, Li H, Chen YY, Wang XJ, Shi GY, Hu QS, Kang XL, Lu Y, Tang XM, Guo QS, Yi J.#. Anthraquinones sensitize tumor cells to arsenic cytotoxicity in vitro and in vivo via reactive oxygen species-mediated dual regulation of apoptosis . Free Radical Biology and Medicine,2004;37(12):2027-2041
18、Yi J. Gao F. Shi G. Li H. Wang Z. Shi X. Tang X.*. The inherent cellular level of reactive oxygen species: One of the mechanisms determing apoptotic susceptibility of leukemic cells to arsenic trioxide. Apoptosis,2002;7(3): 209-215
19、Yi J*, Wang ZW, Cang H, Chen YY, Zhao R, Yu BM, Tang XM. p16 gene methylation in colorectal cancers is associated with Dukes’staging. World Journal of Gastrienterology,2001;7(5):722-725
20、YI J, Yu DR, Chen Y, Xiong W, Li X, Shen J, Tang XM. p16 overexpression in pituitary adenoma studied by immunohistochemistry and in situ hybridization. Chin Med J,2000;113 (2):162-166
21、Yi J and Tang XM. The convergent point of the endocytotic and autophgic pathways . Cell Research,1999; 9(4):243-253
22、Chevalier J, Yi J, Michel O, Tang XM. Biotin and digoxigenin as labels for light and electron microscopy in situ hybridization probes: Where do we stand? . Journal of Histochemistry and Cytochemistry,1997; 45 (4):481-491
23、Yi J, Tang XM. Functional Implication of Autophagy in Steroid-Secreting Cells of the Rat. The Anatomical Record,1995;242(1):137-146
24、Yi J, Michel O, Sassy-Prigent C, Chevalier J. Electron Microscopic Location of mRNA in the rat kidney: improved post-embedding in situ hybridization. Journal of Histochemistry and Cytochemistry,1995; 43(8):801-809


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