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上海交通大学医学院研究生导师简介 王义斌

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 王义斌 专业代码: 071010
性别: 专业名称: 生物化学与分子生物学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: yibinwang@mednet.ucla.edu 重庆南路280号
研究方向 (点击浏览详细信息)
研究细胞生存及死亡过程中,线粒体的调控作用、重要调控基因的改变
探究心血管系统应激反应的细胞内信号网络(network)的奥秘
社会任职
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
11410709000mTORC2的调控机制及其在支链氨基酸调节的心肌细胞死亡中的功能研究上海市科委2012-01~~2013-1225万元课题参与人
Z012BAI02B05系统生物学对代谢疾病的机制和转化的研究科技部2011-12~~2015-12380万元主要责任人
30971094线粒体基质磷酸酶PP2Cm在心力衰竭发生发展过程中的保护作用国家自然科学基金2010-01~~2012-1231万元课题参与人
上海市高校创新团队发展计划上海市教委2009-07~~2012-07300万元子课题负责人
R01 HL088640Revealing Cardiovascular Stress Regulation Beyond the Diffraction Limit2007-04~~2012-03万元主要责任人
PO1-HL080111Mechanisms in Cardiac Ischemia and Protection2005-06~~2010-03万元主要责任人
RO1 HL70079Novel mechanisms of ER stress regulation in heart failure2003-09~~2011-03万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Foster WH, Tidball JG, and Wang Y.#. p38gamma activity is required for maintenance of slow skeletal muscle size.. Muscle Nerve,2012;45(2):266-273
2、Ota A, and Wang Y.#. Cdc37/Hsp90-mediated regulation of IRE1alpha activity in ER stress response and insulin synthesis in INS-1 cells.. J Biol Chem,2012;287(9):6266-6274
3、Sun H, and Wang Y.#. Novel ser/thr protein phosphatases in cell death regulation.. Physiology (Bethesda),2012;27(1):43-52
4、Sun H, Wang Y#. Prostaglandin E2 in remote control of myocardial remodeling.. Circulation,2012;125(23):2818-2820
5、Zhou M, Lu G, Gao C, Wang Y, and Sun H.. Tissue-specific and nutrient regulation of the branched chain alpha-Keto acid dehydrogenase phosphatase.. J Biol Chem,2012;287(28):2397-2406
6、Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, and Jain MK.. Klf15 orchestrates circadian nitrogen homeostasis. Cell Metab,2012;15(3):311-323
7、Huang Y, Zhou M, Sun H, and Wang Y.#. Branched-chain amino acid metabolism in heart disease: an epiphenomenon or a real culprit?. Cardiovasc Res,2011;90(2):220-223
8、Sun H, and Wang Y.#. Restriction of big hearts by a small RNA.. Circ Res,2011;108(3):274-276
9、Sun H, Lu G, Ren S, Chen J, and Wang Y.#. Catabolism of Branched-Chain Amino Acids in Heart Failure: Insights from Genetic Models.. Pediatr Cardiol,2011;32(3):305-310
10、Streicher JM, Kamei K, Ishikawa TO, Herschman H, Wang Y. #. Compensatory hypertrophy induced by ventricular cardiomyocyte specific COX-2 expression in mice. . J Mol Cell Cardiol.,2010;Epub
11、Ahuja P, Zhao P, Angelis E, Ruan H, Korge P, Olson A, Wang Y, Jin ES, Jeffrey FM, Portman M, Maclellan WR.. Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. . J Clin Invest.,2010;120(5):1494-505.
12、Papanicolaou KN, Streicher JM, Ishikawa TO, Herschman H, Wang Y, Walsh K.. Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2. . J Mol Cell Cardiol.,2010;Epub
13、Streicher JM, Ren S, Herschman H, Wang Y. #. MAPK-Activated Protein Kinase-2 in Cardiac Hypertrophy and Cyclooxygenase-2 Regulation in Heart.. Circ Res.,2010;106(8):1434-1443
14、Lu G, Sun H, Korge P, Koehler CM, Weiss JN, Wang Y. #. Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation.. Methods Enzymol.,2009;457:255-273.
15、Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y. #. Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. . J Clin Invest.,2009;119(6):1678-87
16、Ruan H, Li J, Ren S, Gao J, Li G, Kim R, Wu H, Wang Y. #. Inducible and cardiac specific PTEN inactivation protects ischemia/reperfusion injury. . J Mol Cell Cardiol.,2009;46(2):193-200
17、Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. #. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. . Genes Dev.,2007;21(7):784-796.
18、Peter PS, Brady JE, Yan L, Chen W, Engelhardt S, Wang Y#, Sadoshima J, Vatner SF, Vatner DE. . Inhibition of p38alpha MAPK rescues cardiomyopathy induced by overexpressed beta(2)-adrenergic receptor, but not beta(1)-adrenergic receptor. . J Clin Invest.,2007;117(5):1335-1543
19、Ruan H, Mitchell S, Vainoriene M, Lou Q, Xie LH, Ren S, Goldhaber JI, Wang Y. #. Gi alpha1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy.. Circulation.,2007;116(6):596-605
20、Ursitti JA, Petrich BG, Lee PC, Resneck WG, Ye X, Yang J, Randall WR, Bloch RJ, Wang Y. #. Role of an alternatively spliced form of alphaII-spectrin in localization of connexin 43 in cardiomyocytes and regulation by stress-activated protein kinase.. J Mol Cell Cardiol.,2007;42(3):572-581.
21、Lu G, Kang YJ, Han J, Herschman HR, Stefani E, Wang Y. #. TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.. J Biol Chem.,2006;281(9):6087-6095
22、Mitchell S, Ota A, Foster W, Zhang B, Fang Z, Patel S, Nelson SF, Horvath S, Wang Y.#. Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation. . Physiol Genomics.,2006;25(1):50-59
23、Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT.. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. . Genes Dev.,2005;19(10):1175-87.
24、Li M, Georgakopoulos D, Lu G, Hester L, Kass DA, Hasday J, Wang Y.#. p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart. . Circulation.,2005;19(10):1175-87.
25、Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER, Bedja D, Gabrielson KL, Wang Y, Kass DA.. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.. Nature Medicine,2005;11(2):214-222
26、Petrich BG, Eloff BC, Lerner DL, Kovacs A, Saffitz JE, Rosenbaum DS, Wang Y.#. Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.. J Biol Chem.,2004;279(15):15330-15338


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