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上海交通大学医学院研究生导师简介 赵倩

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 赵倩 专业代码: 071010
性别: 专业名称: 生物化学与分子生物学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 硕士生导师 专业学位导师:
联系方式: qzhao@shsmu.edu.cn 地址:上海市重庆南路280号西院2号楼905室邮编:200025电话:021-64666992传真:021-64154900Email: qzhao@shsmu.edu.cn
研究方向 (点击浏览详细信息)
肿瘤细胞分化与凋亡机制研究
社会任职
交通大学医学院病理生理教研室主任
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81172521microRNA 在Snail/Twist诱导乳腺癌细胞发生上皮-间质转化中的表达调控及生物学功能国家自然科学基金2012-01~~2015-1257万元主要责任人
miR-124在乳腺癌细胞EMT过程和小鼠乳腺癌转移中的功能研究 上海交通大学晨星青年学者奖励计划2011-12~~2013-1215万元主要责任人
09SG18低氧诱导因子-1α(HIF-1α)调控microRNAs的功能学研究上海市教委曙光学者计划2009-12~~2012-1215万元主要责任人
30870979低氧诱导因子-1α(HIF-1α)对microRNA的调控及其在白血病细胞分化中的作用国家自然基金委,面上项目2009-01~~2011-1230万元课题负责人
08JC1413500白血病相关蛋白AML1-ETO剪切片断的生物学功能研究上海市基础研究重点项目2008-10~~2010-1030万元课题负责人
2008AA02Z301利用小分子化合物和RNAi研究抗白血病蛋白PLSCR1的作用网络科技部863项目2008-01~~2010-1286万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ. . Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells . Nat Chem Biol.,2012;8(5):486-493
2、Liu XX, Li XJ, Zhang B, Liang YJ, Zhou CX, Cao DX, He M, Chen GQ, He JR, Zhao Q #. MicroRNA-26b is underexpressed in human breast cancer and induces cell apoptosis by targeting SLC7A11. FEBS Lett.,2011;585(9):1363-1367
3、Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ, Zhao Q#. Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis, 2011;32(1):2-9
4、Chen CW, Sowden M, Zhao Q, Wiedmer T, Sims PJ . Nuclear phospholipid scramblase 1 prolongs the mitotic expansion of granulocyte precursors during G-CSF-induced granulopoiesis. J Leukoc Biol.,2011;90 (2):221-33
5、Yan Z, Yang R, Jiang Y, Yang Z, Yang J, Zhao Q, Lu Y. Induction of Apoptosis in Human Promyelocytic Leukemia HL60 Cells by Panaxynol and Panaxydol. Molecules,2011;29;16 (7):5561-73
6、Chen S, Han YH, Zheng Y, Zhao M, Yan H, Zhao Q, Chen GQ, Li D. NDRG1 contributes to retinoic acid-induced differentiation of leukemic cells. Leuk Res.,2009;33(8):1108-1113
7、Chen GQ, Zhang J, Zhao Q. Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells. Chinese Sci Bull,2009;54(18): 2759-2765
8、Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ. Hypoxia-inducible factor-1alpha-induced differentiation of myeloid leukemic cells is its transcriptional activity independent . Oncogene,2008;27(4):519-27
9、Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ. Accumulation of hypoxia-inducible factor-1{alpha} protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica,2008;93(10):1480-7
10、Huang Y, Zhao Q, Chen GQ. phospholipid scramblase 1. . Acta Physiologica Sinica,2006;58(6):501-510
11、Chen GQ, Peng ZG, Liu W, Song LP, Jiang Y, Huang Y, Zhao Q.. Hypoxia inducible factor-1alpha and leukemic cell differentiation. Acta Physiologica Sinica,2006;58(1): 5-13
12、Huang Y, Zhao Q*, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ.. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.. Oncogene,2006;25(50):6618-27
13、Ren HY,Cao Y,Zhao QJ, Li J, Zhou CX, Liao LM, Jia MY, Zhao Q, Cai HG, Han ZC, Yang RC, Chen GQ, Zhao R.C. . Proliferation and diferentiation of bone marrow stromal cells under hypoxic conditions . Biochem Biophys Res Commun.,2006;347: 12-21
14、Zhao KW, Li D, Zhao Q, Huang Y, Silverman RH, Sims PJ, Chen GQ . Interferon-alpha-induced expression of phospholipid scramblase 1 through STAT1 requires the sequential activation of protein kinase Cdelta and JNK. J Biol Chem.,2005;280(52): 42707-42714
15、Yan H, Peng ZG, Wu YL, Jiang Y, Yu Y, Huang Y, Zhu YS, Zhao Q, Chen GQ. Hypoxia-simulating agents and selective stimulation of arsenic trioxide-induced growth arrest and cell differentiation in acute promyelocytic leukemic cells. Haematologica,2005;90(12): 1607-1616
16、Xue ZH, Jiang Y, Yu Y, Wang LS, Chen GQ,Zhao Q#. Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1α protein . Biochem Biophys Res Commun.,2005;332(4),1140-1145
17、Zhao KW, Li X, Zhao Q*, Huang Y, Peng ZG, Shen WZ, Zhao J, Zhou QS, Chen Z, Sims PJ, Wiedmer T, Chen GQ . Protein Kinase Cdelta Mediates Retinoic Acid and Phorbol Myristate Acetate-induced Phospholipid Scramblase 1 Gene Expression: Its Role in Leukemic Cell Differentiation. BLOOD,2004; 104(12): 3731-8.
18、Zhao Q, Tao J, Zhu Q, Jia PM, Dou AX, Li X, Cheng F, Waxman S, Chen GQ, Chen SJ, Lanotte M, Chen Z, Tong JH. Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation. Leukemia,2004;18 (2): 285-92


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