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上海交通大学医学院研究生导师简介 沈浩

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 沈浩 专业代码: 100102
性别: 专业名称: 免疫学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: hshen@mail.med.upenn.edu 上海交通大学医学院、上海市免疫学研究所上海市重庆南路280号 邮编:200025hshen@sjtu.edu.cn
研究方向 (点击浏览详细信息)
感染免疫和病原微生物
社会任职
免疫学核心期刊Journal of Immunology副主编、栏目编辑
美国微生物学会会员
美国免疫学学会会员
美国科学促进会会员
国际学术期刊Science、Nature、Nature Medicine等的评阅人
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
2011CB512104记忆性T细胞分化和功能的表观遗传组学调控机制中华人民共和国科技部2011-01~~2013-0865万元课题负责人
2011CB512104HDACi as immunotherapeutics for HIV progressorsNIH/NIAID2010-09~~2013-08$2.4/年万元课题负责人
Development of a novel protein based adjuvantNIH/NIAID2010-07~~2012-06$2.4/年万元课题负责人
AI 1R21AI079724-01Molecular basis of defective CD8 T cells during chronic viral infectionNIH/NIAID2009-05~~2011-04$15/年万元课题负责人
U19 AI083022Shaping Antiviral Immunity by inflammationNIH/NIAID2009-05~~2014-04$27.5/年万元课题负责人
R41 AI068290New Attenuated Anthrax VaccineNIH/NIAID2006-08~~2010-07$80万元课题负责人
Modulation of Cellular Immune Responses by Bordelella sppPM External Research Program2003-06~~2007-05$111万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Meriem Boukherouba,王树军,刘芝翠,李金枝,张勇,王佳琦,沈浩,潘萌,王颖. Ⅰ型干扰素参与调节SLE外周T细胞活化和TLR表达谱的研究. 现代免疫学,2012;32(5):0353-0358
2、Adriana R. Mantegazza, Susan H. Guttentag, Jamel El-Benna, Miwa Sasai,7 Akiko Iwasaki, Hao Shen, Terri M. Laufer, and Michael S. Marks. Adaptor Protein-3 in Dendritic Cells Facilitates Phagosomal Toll-like Receptor Signalingand Antigen Presentation to CD4+ T Cells. Immunity,2012;36:782–794
3、Asma khanniche,王颖,沙巍,孙勤,曾维宏,赖允鑫,肖和平,沈浩#. Th1和Th17细胞在活动期肺结核病患者外周比例失衡的临床研究. 现代免疫学,2012;32(5):0387-0392
4、刘芝翠,王树军,曾维宏,张勇,沈浩,朱承,王颖. T细胞活化促进B细胞产生抗体机制的研究. 现代免疫学,2012;32(6):0450-0456
5、Devon J. Shedlock, Kendra T. Talbott Christina, Cress, Bernadette Ferraro, Steven Tuyishme, Karthik Mallilankaraman, Neil J. Cisper, Matthew P. Morrow, Stephan J. Wu, Omkar U. Kawalekar, Amir S. Khan, Niranjan Y. Sardesai, Karuppiah Muthumani, Hao Shen, David B. Weiner. A highly optimized DNA vaccine confers complete protective immunity against high-dose lethal lymphocytic choriomeningitis virus challenge. Vaccine,2011;29 :6755– 6762
6、沈浩,王颖,王佳琦,李宁丽,王宏林,沈南. 重要自身免疫性疾病的发病机制及其免疫干预策略. 上海交通大学学报(医学版),2011;31(5):0353-0357
7、李金枝,丁隽,李昊文,张勇,沈浩,陈学进,王树军,王颖. Pristance 诱导小鼠系统性红斑狼疮动物模型的研究. 细胞与分子免疫学杂志,2011;27(2):119-121
8、DiSpirito JR,Shen H#. Quick to remember, slow to forget: rapid recall responses of memory CD8+ T cells. Cell Res,2010;20(1):13-23
9、DiSpirito JR,Shen H#. Histone acetylation at the single cell level: a marker of memory CD8 T cell differentiation and functionality. J Immunol,2010;184(9):4631-4636
10、DiSpirito JR, and Shen H. Identification of the stimulation-induced transcriptional signatures of na?ve and memory CD8+ T cells. J Immunol,2010;revision
11、Priatel JJ, Chen X, Huang YH, Chow MT, Zenewicz LA, Coughlin JJ, Shen H, Stone JC, Tan R, Teh HS. RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells. J Immunol,2010;184(2):666-76
12、Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H#, Yang X, Chen YH. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell,2009;133(3):415-426
13、Bian C, Zhang X, Cai X, Zhang L, Chen Z, Zha Y, Xu Y, Xu K, Lu W, Yan L, Yuan J, Feng J, Hao P, Wang Q, Zhao G, Liu G, Zhu X, Shen H, Zheng B, Shen B, Sun B. Conserved amino acids W423 and N424 in receptor-binding domain of SARS-CoV are potential targets for therapeutic monoclonal antibody. Virology,2009;383(1):39-46
14、Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, Jones RG, Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature,2009;460(7251):103-7
15、Jiang J, Bennett AJ, Fisher E, Williams-Bey Y, Shen H, Murasko DM. Limited expansion of virus-specific CD8 T cells in the aged environment. Mech Ageing Dev,2009;130(11-12):713-21
16、Mousavi SF, Soroosh P, Takahashi T, Yoshikai Y, Shen H, Lefran?ois L, Borst J, Sugamura K, Ishii N. OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells. J Immunol,2008;181(9):5990-6001
17、Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H#, Wherry EJ, Reiner SL. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med,2008;204(9):2015-2021
18、Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, Chen YH. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell,2008;133(3):415-26
19、Northrop JK, Wells AD, Shen H#. Cutting Edge: Chromatin remodeling as a molecular basis for enhanced functionality of memory CD8 T cells. J Immunol,2008;181(2):865-8
20、Pearce EL,Shen H#. Generation of CD8 T cell memory Is Regulated by Interleukin-12. J Immunol,2007;179(4):2074-2081
21、Krawczyk CM, Shen H, Pearce EJ. Functional plasticity in memory T helper cell responses. J Immunol,2007;178(7):4080-8
22、Ekkens MJ, Shedlock DJ, Jung E, Troy A, Pearce EL, Shen H, Pearce EJ. Th1 and Th2 cells help CD8 T cell responses. Infect Immun,2007;75(5):2291-6
23、Krawczyk CM, Shen H, Pearce EJ. Memory CD4 T cells enhance primary CD8 T-cell responses. Infect Immun,2007;75(7):3556-60
24、Priatel JJ, Chen X, Zenewicz LA, Shen H, Harder KW, Horwitz MC, Teh HS. Chronic immunodeficiency in mice lacking rasgrp1 results in cd4 t cell immune activation and exhaustion. J Immunol,2007;179(4):2143-52
25、Jones RG, Bui T, White C, Madesh M, Krawczyk CM, Lindsten T, Hawkins BJ, Kubek S, Frauwirth KA, Wang LY, Conway SJ, Roderick HL, Bootman MD, Shen H, Foskett JK, Thompson CB. Bax and Bak regulate T cell proliferation through control of ER Ca homeostasis. Immunity,2007;27(2):268-80
26、Fang CY, Miwa T, Shen H, Song WC. Complement-dependent enhancement of CD8+ T cell immunity to lymphocytic choriomeningitis virus infection in decay-accelerating factor deficient mice. J Immunol,2007;179(5):3178-86
27、Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H, Wherry EJ, Reiner SL. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. J Exp Med,2007;204(9):2015-21


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