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上海交通大学医学院研究生导师简介 郭晓奎

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 郭晓奎 专业代码: 100103
性别: 专业名称: 病原生物学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: Microbiology@sjtu.edu.cn 上海市重庆南路280号上海交通大学医学院病原生物学教研室 200025
研究方向 (点击浏览详细信息)
分子细菌学;益生菌的安全性;微生物检测
社会任职
上海市医学微生物学专业委员会主任委员
上海市预防医学会微生态学专业委员会副主任委员
上海市食品学会乳酸菌专业委员会副主任委员
上海市海洋微生物学专业委员会副主任委员
上海市医学病毒学专科学会委员
中华预防医学会微生态学分会委员, 基础微生态学组副组长
中国医学微生物学和免疫学专业委员会委员
中国人兽共患病病原专业委员会委员
中国微生物学会普及与教育工作委员会委员
中国微生物学会普及与教育工作委员会委员
《中国人兽共患病学报》副主编
《中国微生态学杂志》编委
《国际生物制品学杂志》编委
《微生物与感染杂志》编委
《上海交通大学学报》(医学版)编委
《医学参考报》(微生物学与免疫学)编委
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
81171587基于Pan-genome技术探究问号钩端螺旋体不同血清型致病性差异的遗传基础国家自然科学基金2012-01~~2015-1258万元课题负责人
2011AA02A100自动化临床微生物分析检测仪器的研制863重大专项2011-09~~2015-12300万元课题负责人
10JC1408200重要人兽共患病钩端螺旋体病通用疫苗的基础研究上海市科委2010-10~~2012-0930万元课题负责人
09XD1402700钩端螺旋体rel基因致病机理的研究上海市科委2009-07~~2011-0640万元课题负责人
30770111钩端螺旋体比较蛋白质组学研究国家自然科学基金2008-01~~2010-1230万元课题负责人
2008ZX10004-002呼吸道感染和感染性腹泻病原体诊断和组合检测技术“十一五”重大专项子课题2008-01~~2010-12300万元子课题负责人
30670102钩体血清型相关基因的研究国家自然科学基金2007-01~~2009-1226万元课题负责人
2006AA02Z176钩端螺旋体重要功能基因的发掘、鉴定和应用国家科技部 “863”计划2006-01~~2008-12330万元课题负责人
30370071钩端螺旋体溶血素基因结构、表达及功能的研究国家自然科学基金2004-01~~2006-1220万元课题负责人
2003AA223030钩端螺旋体致病及免疫机理的功能基因组学研究国家科技部 “863”计划2004-01~~2005-12157.3万元课题负责人
2001AA223030钩端螺旋体致病及免疫机理的功能基因组学研究国家科技部 “863”计划2001-01~~2003-12141.1万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Zhou Y, Tao J, Yu H, Ni JJ, Zeng LB, Teng QH, Kim K, Zhao GP, Guo XK*#, and Yao YF*. Hcp-family proteins secreted via type VI secretion system coordinately regulate Escherichia coli K1 interaction with human brain microvascular endothelial cells. Infection and Immunity,2012;80(3):1243-51
2、Wei YX, Zhang ZY, Liu C, Malakar PK, Guo XK*#. Safety assessment of Bifidobacterium longum JDM301 based on complete genome sequences. World J Gastroenterol,2012;18(5):479-88
3、Zelin Cui, Yuhua Zhou, Hong Li, Yan Zhang, Shenjie Tang, Xiaokui Guo*#. Complex sputum microbial composition in patients with pulmonary tuberculosis. BMC microbiology,2012;12:276
4、Zhang ZY, Liu C, Zhu YZ, Wei YX, Tian F, Zhao GP, Guo XK*#. Safety assessment of Lactobacillus plantarumJDM1 based on the complete genome. Int J Food Microbiol,2012;153(1-2):166-70
5、Zelin Cui, Zhen Song, Yanchun Wang, LingbingZeng, WenbinShen, Zheng Wang, Qingtian Li, Ping He, Jinhong Qin*, and Xiao-Kui Guo*#. Complete Genome Sequence of wide host-range Staphylococcus aureus phage JD007. Journal of Virology,2012;86(24):13880
6、Zelin Cui, WenbinShen, Zheng Wang, Haotian Zhang, Rao Me, Yanchun Wang, LingbingZeng, Yongzhang Zhu, Jinhong Qin, Ping He*, and Xiao-Kui Guo*#. Complete Genome Sequence of Klebsiellapneumoniae phage JD001. Journal of Virology,2012;86(24):13843
7、Zhong Y, Chang X, Cao XJ, Zhang Y, Zheng H, Zhu Y, Cai C, Cui Z, Zhang Y, Li YY, Jiang XG, Zhao GP, Wang S, Li Y, Zeng R, Li X, Guo XK#. A novel sequence-based coa genotyping Comparative proteogenomic analysis of the Leptospira interrogans virulence-attenuated strain IPAV against the pathogenic strain 56601. Cell Research,2011;21(8):1210-1229
8、Zhang ZY, Sun ZQ, Wang ZL, Wen ZL, Sun QW, Zhu ZQ, Song YZ, Zhao JW, Wang HH, Zhang SL, Guo XK#. Complete genome of a novel clinical isolated non-tuberculous mycobacterium strain JDM601.. 2011, 193 (16): 4300-1. J Bacteriol,2011;193 (16):4300-4301
9、Zhang SM, Tian F, Huang QF, Zhao YF, Guo XK#, Zhang FQ. Bacterial diversity of subgingival plaque in 6 healthy Chinese individuals. Exp Ther Med,2011;2(5):1023-1029
10、Li QT, Zhou YH, Dong K, Guo XK. #. Potential therapeutic efficacy of a bactericidal-immunomodulatory fusion peptide against methicillin-resistant Staphylococcus aureus skin infection. . Appl Microbiol Biotechnol.,2010;86(1):305-9
11、Liu C, Zhang ZY, Dong K, Guo XK#. Adhesion and immunomodulatory properties of Bifidobacterium lactis HN019 to intestinal epithelial cells INT-407. . World Journal of Gastroenterology,2010;16 (18):2283-2290
12、Dong K, Li QT, Liu C, Zhang YY, Zhao GP, Guo XK. #. Cloning and characterization of three cheB genes in Leptospira interrogans . Acta Biochim Biophys Sin (Shanghai),2010;42 (3):216-223
13、Cai CS, Zhu YZ, Zhong Y, Xin XF, Jiang XG, Lou XL, He P, Qin JH, Zhao GP, Wang SY, Guo XK#. Development of O-antigen gene cluster-specific PCRs for rapid typing six epidemic serogroups of Leptospira in China. . BMC microbiology,2010;10(67):1230-1236
14、Yuhua Zhou, Qingtian Li, Lizhong Han, Ping Lin, Huajun Zheng, Yanxia Wei, Zelin Cui, Yuxing Ni, Xiaokui Guo#. The microbiota analyses of sputum from the patients of lower respiratory tract infection using 16S rDNA pyro-sequencing. 42 :754-761. Acta Biochim Biophys Sin,2010;42:754-761
15、Yan-Xia Wei, Zhuo-Yang Zhang, Chang Liu,Yong-Zhang Zhu, Yong-Qiang Zhu, Hua-Jun Zheng, Guo-Ping Zhao, Sheng-Yue Wang, and Xiao-Kui Guo#. Complete Genome Sequence of Bifidobacterium longum JDM301. . J. Bacteriol,2010;192(15):4076-4077
16、Zhu YZ, Cai CS, Zhang W, Guo HX, Zhang JP, Ma GY, Ji YY, Wu JL, Li QT, Lu CP, Guo XK#. Immunoproteomic Analysis of Human Serological Antibody Responses to Vaccination with Whole-Cell Pertussis Vaccine (WCV). PLoS ONE,2010;5(11):13915-13915
17、Yuan JP, Li P, Tao J, Shi XD, Hu BY, Chen HB, Guo XK#. H.pylori Escape Host Immunoreaction Through Inhibiting ILK Expression By VacA. . Cellular & Molecular Immunology,2009;6(3):91-97
18、Zhang ZY, Liu C, Zhu YZ, Zhong Y, Zhu YQ, Zheng HJ, Zhao GP, Wang SY, Guo XK#. Complete genome sequence of Lactobacillus plantarum JDM1.. J. Bacteriol.,2009;191(15):5020-5021
19、Zhang SM, Tian F, Jiang XQ, Li J, Xu C,Guo XK#, Zhang FQ. . Evidence for calcifying nanoparticles in gingival crevicular fluid and dental calculus in periodontitis.. Journal of Periodontology,2009;80 (9):1462-1470
20、Tian F, Yu Y, Chen B, Li HR, Yao YF, Guo XK#. Bacterial, archaeal and eukaryotic diversity in Arctic sediment as revealed by 16S rRNA and 18S rRNA gene clone libraries analysis. . Polar Biology,2009;32 (1):93-103
21、Zhao W, Chen CY, Zhang XY, Lai WQ, Hu BY, Zhao GP, Qin JH, Guo XK#. Molecular characterization of the pL40 protein in Leptospira interrogans . Can. J. Microbiol,2009;55 (6):739-749
22、Feng CY, Li QT, Zhang XY, Dong K, Hu BY, Guo XK#. Immune strategies on single component LipL32 and multi-components recombinant LipL32-41-OmpL1 vaccines against Leptospira. . Brazilian Journal of Medical and Biological Research,2009;42(9):796-803
23、Liu C, Zhang ZY, Dong K, Yuan JP,Guo XK#. Antibiotic resistance of probiotic strains of lactic acid bacteria isolated from marketing food and drugs.. Biomedical and Enviromental Science,2009;22(5):401-412
24、Zhu YZ, Li QT, Wang L, Zhong Y, Ding GH, Li G, Jia PL, Shi TL, Guo XK#. Gene Expression Profiling-Based In Silico Approach to Identify Potential Vaccine Candidates and Drug Targets against B. pertussis and B. parapertussis.. OMICS,2008;12 (3):161-169
25、Qin JH, Zhang Q, Zhang ZM, Zhong Y, Yang Y, Hu BY, Zhao GP, Guo XK#. Identification of a novel prophage-like gene cluster actively expressed in both virulent and avirulent strains of Leptospira interrogans serovar lai.. Infect Immun,2008;76(6):2411-9
26、He P, Sheng YY, Shi YZ, Jiang XG, Qin JH, Zhang ZM, Zhang GP, Guo XK#. Genetic diversity among major endemic strains of Leptospira interrogans in China. BMC Genomics,2008;8(14):204-7
27、Guo XK*, Zhao WQ, Kondo C, Shimojo N, Yamashita K, Aoki T, Hayakawa T. Tissue inhibitors of metalloproteinases-1 (TIMP-1) and-2(TIMP-2) are major serum factors that stimulate the TIMP-1 gene in human gingival fibroblasts. . BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH,2007;1763(3):296-304
28、Yang HL, Zhu YZ, Qin JH, He P, Jiang XC, Zhao GP, Guo XK#. In silico and microarray-based genomic approaches to identifying potential vaccine candidates against Leptospira interrogans. . BMC Genomics,2006;16(7):293-240
29、Li ZH, Dong K, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK#. Characterization of the cheY genes from Leptospira interrogans and their effects on the behavior of Escherichia coli. . Biochem Biophys Res Commun,2006;345(2):858-866
30、Qin JH, Sheng YY, Zhang ZM, Shi XZ, He P, Hu BY, Yang Y, Liu SG, Zhao GP, Guo XK#. Genome-wide transcriptional analysis of temperature shift in L. interrogans serovar lai strain 56601. BMC Microbiology,2006;6(51):1-10
31、Yang HL, Jiang XC, Zhang XY, Li WJ, Hu BY, Zhao GP, Guo XK#. Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation. . BMC Infect Dis,2006;6(1):19-25
32、Li QT, Zhu YZ, Chu JY, Wang YY, Xu YH, Hou QM, Zhang SM, Guo XK#. Protective immunity against Bordetella pertussis by a recombinant DNA vaccine and the effect of coinjection with a granulocyte-macrophage colony stimulating factor gene. . Microbiol Immunol,2006;50(12):929-36.
33、Li QT, Zhu YZ, Chu JY, Dong K, He P, Feng CY, Hu BY, Zhang SM, Guo XK#. Granulocyte-macrophage Colony-stimulating Factor DNA Prime-protein Boost Strategy to Enhance the Efficacy of a Recombinant Pertussis DNA Vaccine . Acta Pharmacologica Sinica,2006;27 (11):1487-1494
34、Sun JC, Xu JL, Cao JP, Liu Q, Guo XK#, Shi TL. Prediction and systematic study of protein-protein interaction networks of Leptospira interrogans.. Chinese science Bulletin,2006;51(1):1-10
35、Li ZH, Dong K, Sun JC, Yuan JP, Hu BY, Liu JX, Zhao GP, Guo XK#. Characterization of cheW Genes of Leptospira interrogans and Their Effects in Escherichia coli. . Acta Biochim Biophys Sin,2006;38(2):79-88


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