上海交通大学医学院研究生导师简介陈国强

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上海交通大学免费考研网/2013-01-09

基本信息

导师姓名:	陈国强	专业代码:	100104
性别:	男	专业名称:	病理学与病理生理学
培养单位:	基础医学院	三级学科/ 专业领域:	未设
导师类型:	博士生导师	专业学位导师:
联系方式:	chengq@shsmu.edu.cn 重庆南路280号，新教学楼905室，200025，64154900

研究方向 (点击浏览详细信息)

肿瘤发病学和治疗学基础研究

社会任职

国务院学位委员会第六届学科评议组基础医学组成员

中国病理生理学学会任常务理事

《癌症》、《生理学报》、《国际病理和临床科学杂志》副主编

美国血液学会、美国生物化学和分子生物学学会和美国化学学会会员

中国生物化学与分子生物学学会常务理事、中国生物化学与分子生物学学会医学分会副理事长

上海生物化学与分子生物学学会副理事长

《中国科学——生命科学》、《科学通报》、《中华医学杂志》、《中华肿瘤防治杂志》、《中国病理生理学杂志》、《Frontiers of Medicine in China》、《IJBMB 》、《Chemico-Biological Interactions》、《AJBR》等编委

上海生理学会理事长

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
11JC1406800	SUMO-E3连接酶Pc2调控HIF-1活性和促进VEGF表达的机制	上海市科委基础研究重点项目（连续支持）	2012-01~~2014-12	30万元	课题负责人
2009CB918404	蛋白质翻译后修饰的发生与调控机制及其生理病理效应	国家重大研究计划（首席科学家）	2009-01~~2013-08	840万元	课题负责人
90813034	白血病细胞分化与凋亡信息基础的化学生物学研究	国家自然基金委,重点项目	2009-01~~2012-12	250万元	课题负责人
08JC1413700	造血相关转录因子抑制HIF-1的转录活性和肿瘤血管形成的实验研究	上海市科委重点项目	2008-10~~2010-09	30万元	课题负责人
KSCX2-YW-R-097	白血病细胞分化和凋亡信息基础研究	中国科学院知识创新工程重要方向性研究	2007-10~~2010-10	150万元	课题负责人
07HX21001	低氧诱导因子和白血病细胞分化的系统研究	横向课题	2007-01~~2009-12	77.9万元	课题负责人
30630034	低氧诱导因子和白血病细胞分化的系统研究	国家自然基金委,重点项目	2007-01~~2010-12	150万元	课题负责人
LJ06020	白血病细胞分化新信号机制的系统研究	上海市卫生局,医学领军人才	2006-01~~2010-12	50万元	课题负责人
05JC14032	白血病细胞分化新机制的深入研究	上海市科委,重点科技攻关	2005-10~~2007-09	50万元	课题负责人
90408009	以自主的原创性模型研究白血病细胞分化的信息基础	国家自然基金委,面上项目	2005-01~~2007-12	35万元	课题负责人
2002CB512805	利用蛋白质-蛋白质相互作用信息发现针对M2b型白血病的药物靶标	国家973项目	2002-12~~2008-09	444万元	课题负责人

学术论文 (#为通讯作者,*为共同第一作者)

1、Liu B, Zheng Y, Wang TD, Xu HZ, Xia L, Zhang J, Wu YL, Chen GQ#, Wang LS. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. J Proteome Res,2012;11(3):1773-81.
2、Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ#. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells. Nat Chem Biol,2012;8(5):486-93.
3、Wang LS, Xia L, Shen SM, Zheng Y, Yu Y, Chen GQ#. Dissecting cell death with proteomic scalpels. Proteomics,2012;12(4-5):597-606.
4、Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ#. PML-RARalpha enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway. Autophagy,2011;7(10):1132-44.
5、Zhao XY, Zhao KW, Jiang Y, Zhao M, Chen GQ #. Synergistic Induction of Galectin-1 by CCAAT/Enhancer Binding Protein Alpha and Hypoxia-inducible Factor 1Alpha and Its Role in Differentiation of Acute Myeloid Leukemic Cells. J Biol Chem,2011;286(42):36808-36819.
6、Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ#, Zhao Q . Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. Carcinogenesis,2011;32(1):2-9.
7、Xu Y, Li J, Zuo Y, Deng J, Wang LS, Chen GQ#. SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors. Cancer Lett,2011;309(1):78-84.
8、Shen SM, Yu Y, Wu ZX, Zheng Y, Chen GQ#, Wang LS. Apoptosis-inducing factor is a target gene of C/EBPalpha and participates in adipocyte differentiation. FEBS Lett,2011;585(14):2307-12.
9、Duan XF, Wu YL, Xu HZ, Zhao M, Zhuang HY, Wang XD, Yan H, Chen GQ#. Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes.. Chem Biol Interact,2010;183 : 222-230.
10、Shen SM, Yu Y, Wu YL, Cheng JK, Wang LS, Chen GQ #. Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells.. Carcinogenesis,2010;31(3):419-426.
11、Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ#. The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation.. Leukemia,2010;24(3):544-551.
12、Gu ZM, Wu YL, Zhou MY, Liu CX, Xu HZ, Yan H, Zhao Y, Huang Y, Sun HD, Chen GQ#. Pharicin B stabilizes retinoic acid receptor-a and presents synergisticdifferentiation induction with ATRA in myeloid leukemic cells. Blood,2010;116(24):5289-5297.
13、Zhao XY, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ#, Zhao KW. Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells. Carcinogenesis,2010;31(8):1367-1375
14、Xu Y, Zuo Y, Zhang HZ, Kang XL, Yue F, Yi ZF, Liu MY, Edward T. H. Yeh, Chen GQ#, Cheng JK . Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis. The Journal of Biological Chemistry,2010;285(47):36682-36688
15、Wu YL, Zhou HC, Chen GQ#. Molecular mechanisms of leukemia-associated protein degradation. Front Med China,2010;4(4):363-370
16、Xu HZ, Huang Y, Wu YL, Zhao Y, Xiao WL, Lin QS, Sun HD, Dai W, Chen GQ#. Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function. Cell Cycle,2010;9(14):1-11.
17、Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ#. Protein kinase Cd stimulates proteasome-dependent degradation of C/EBPα during apoptosis induction of leukemic cells. . PlosONE,2009;4(8): e6552
18、Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, Chen GQ #. NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCd and apoptosis.. Proteomics,2009;9(8):2064–2075.
19、Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ#. Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis.. Apoptosis,2009;14(5):699–710.
20、Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ #. Proteomics-based identification of two novel direct targets of hypoxia- inducible factor-1a and their potential roles in migration/invasion of cancer cells.. Proteomics,2009;9(15):3901-3912.
21、Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ#. Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction.. Exp Cell Res,2009;315(19):3250-3258.
22、Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ#. Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity.. Leukemia,2008;22(2):378–386.
23、Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ#. Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1a.. Oncogene,2008;27(6):839–847.
24、Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ#. Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent.. Oncogene,2008;27(4):519–527.
25、Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ#. Accumulation of hypoxia-inducible factor-1a protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid.. Haematologica,2008;93(10):1480-1487.
26、Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL and Chen GQ. CCAAT/enhancer-binding protein a antagonizes transcriptional activity of hypoxia-inducible factor 1 a with direct protein–protein interaction.. Carcinogenesis,2008;29(2):291–298.
27、Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ#. Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd.. Leukemia,2007;21 (7):1488-1495.
28、Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ #. Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells. . J Proteome Res,2007;6(9): 3808-3818.
29、Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ #. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia.. Blood,2006;107 (2):698-707.
30、Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ#. Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells.. Oncogene,2006;25 (50): 6618-6627.
31、Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ#. Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cd-dependent mechanisms.. Blood,2005;105(9):3714-3721.
32、Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ#. Protein kinase Cd mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation. Blood,2004;104(12): 3731-3738.