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上海交通大学医学院研究生导师简介 傅国辉

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 傅国辉 专业代码: 100104
性别: 专业名称: 病理学与病理生理学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: fuguhu@263.net 重庆南路280号1号楼206联系电话63846590-776601
研究方向 (点击浏览详细信息)
肿瘤的靶向治疗膜蛋白质病理学
社会任职
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
2011BA203191基于分子标志物的胃癌早期诊断、分子分型十二五攀登计划(子课题)2013-01~~2015-12240万元子课题负责人
SQ2012CC037148赖氨酸翻译后修饰及对蛋白质功能的调控作用973重大研究项目2013-01~~2017-1280万元子课题负责人
81171939NF-kB p65/miR-23a-27a-24-2 cluster负反馈调控异常在低分化胃腺癌发生及红系分化障碍中作用的研究国家自然基金委,面上项目2012-01~~2016-1260万元课题负责人
20100073110067miR-23-24-27 cluster在胃癌发生中作用的研究教育部博士点基金2011-01~~2013-126万元课题负责人
30971115microRNA在红细胞终极分化及胃癌发生中关联作用的研究国家自然基金,面上项目2010-01~~2012-1235万元课题负责人
2008AA02Z120阴离子交换蛋白1基因突变及表达异常在胃癌诊断治疗中的应用863科技部2008-01~~2010-12288万元课题负责人
30770960阴离子交换蛋白异常在胃癌发生中作用的研究国家自然基金委,面上项目2008-01~~2010-1234万元课题负责人
08JC1413400NF-κB p65激动剂与胃泌素联合降低胃粘膜局部酸碱度对造血干细胞转化为胃癌的阻断作用研究上海市科委基础重点项目2008-01~~2011-1210万元课题负责人
30770960阴离子交换蛋白异常在胃癌发生中作用的研究国家自然基金委,面上项目2008-01~~2010-1234万元课题负责人
30570697p16功能调控的新机制及其肿瘤相关性研究国家自然基金委,面上项目2006-01~~2008-1225万元课题负责人
30230160带3蛋白C端域在细胞增殖和凋亡过程中作用的 研究国家自然基金重点项目2003-01~~2005-12100万元课题负责人
30170348 红细胞膜带3蛋白C端域与血型糖蛋白A相互作用的研究国家自然基金面上项目2002-01~~2002-1218万元课题负责人
39970291Band3蛋白关联的一种新活性蛋白酶的纯化、基因克隆及其特性研究国家自然基金面上项目2000-01~~2002-1211万元课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Suo WH, Zhang N, Wu PP, Zhao L, Song LJ, Shen WW, Zheng L, Tao J, Long XD, Fu GH.#. Anti-tumor effects of small interfering RNA targeting anion exchanger 1 in experimental gastric cancer.. Br J Pharmacol,2012;165(1):135-47
2、Wang T, Zhao L, Yang Y, Tian H, Suo WH, Yan M, Fu GH.#. EGR1 is critical for gastrin-dependent upregulation of anion exchanger 2 in gastric cancer cells.. FEBS J,2012 Nov 5.;Epub ahead of print
3、Song LJ, Liu RJ, Zeng Z, Alper SL, Cui HJ, Lu Y, Zheng L, Yan ZW, Fu GH.#. Gastrin inhibits a novel, pathological colon cancer signaling pathway involving EGR1, AE2, and P-ERK. J Mol Med,2012;90(6):707-18
4、Wang P, Mei J, Tao J, Zhang N, Tian H, Fu GH.#. Effects of Helicobacter pylori on biological characteristics of gastric epithelial cells.. Histol Histopathol,2012;27(8):1079-91
5、Wang P, Mei J, Zhang N, Tao J, Tian H, Fu GH#. Helicobacter pylori upregulates the expression of p16(INK4) in gastric cancer cells.. Hepatogastroenterology,2011;58(107-108):846-53
6、Zhao L, Long XD, Yao JG, Wang C, Ma Y, Huang YZ, Li YQ, Wang MF, Fu GH#. Genetic polymorphism of XRCC3 codon 241 and Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi Population, China: a hospital-based case-control study. Cancer Epidemiol.,2011;35(6):564-8
7、Wu J,Zhang YC,Suo WH,Liu XB,Shen WW,Tian H,Fu GH#. Induction of anion exchanger-1 translation and its opposite roles in the carcinogenesis of gastric cancer cells and differentiation of K562 cells.. Oncogene,2010;29(13):1987-96
8、Long XD, Ma Y, Huang YZ, Yi Y, Liang QX, Ma AM, Zeng LP, Fu GH.#. Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favoring growth inhibition of gastric cancer cells.. Mol Carcinog,2010;Jun;49(6):611-8
9、Tian H, Zhang N, Suo WH, Wang T, Song LJ, Wu J, Liu Q, Shen WW, Fu GH#. Gastrin suppresses the interdependent expression of p16 and anion exchanger 1 favouring growth inhibition of gastric cancer cells. Int J Cancer,2010;1;127(6):1462-74
10、Long XD, Ma Y, Zhou YF, Ma AM, Fu GH#. Polymorphism in xeroderma pigmentosum complementation group C codon 939 and aflatoxin B1-related hepatocellular carcinoma in the Guangxi population. Hepatology,2010;52(4):1301-9
11、Xu WQ, Song LJ, Liu Q, Zhao L, Zheng L, Yan ZW, Fu GH. #. Expression of anion exchanger 1 is associated with tumor progress in human gastric cancer.. J Cancer Res Clin Oncol,2009;135(10):1323-30
12、Zhao W, Zhu F, Shen W, Fu A, Zheng L, Yan Z, Zhao L, Fu G#. Protective effects of DIDS against ethanol-induced gastric mucosal injury in rats. Acta Biochim Biophys Sin,2009;41(4):301-8
13、Liu Q, Song LJ, Xu WQ, Zhao L, Zheng L, Yan ZW, Fu GH.#. Expression of cytoplasmic p16 and anion exchanger 1 is associated with the invasion and absence of lymph metastasis in gastric carcinoma.. Mol Med Report,2009;2(2):169-74
14、Yang Y, Wu PP, Wu J, Shen WW, Wu YL, Fu AF, Zheng L, Jin XL, Fu GH.#. Expression of anion exchanger 2 in human gastric cancer. . Exp Oncol.,2008;30(1):81-7
15、Wang Y, Wu SF, Chen GQ, Fu GH #. Effect of block deletions in the C-terminus on the functional expression of human anion exchanger 1 (AE1). . Mol Membr Biol,2007;24(1):65-73
16、Wei-Wei Shen, Jun Wu, Li Cai, Bing-Ya Liu, Yan Gao, Guo-Qiang Chen, Guo-Hui Fu #. Expression of anion exchanger 1 sequestrates p16 in cytoplasm in gastric and colonic adenocarcinoma. . Neoplasia,2007;9(10):812-9.
17、Xiao-Yan Pan, Guo-Qiang Chen, Li Cai, Guo-Hui Fu#. Anion exchanger 2 mediates the action of arsenic trioxide. . British Journal of Haematology,2006;134:491-499
18、Guo-Hui Fu (Fu GH)*, Yong Wang, Yu-Hui Xi, Wei-Wei Shen, Xiao-Yan Pan, Wu-Zhong Shen, Guo-Qiang Chen.. Direct interaction and cooperative role of tumor suppressorp16 with band 3(AE1). . FEBS Letters,2005;579:2105-2110
19、Guo-Hui Fu#, Yong Wang, Yu-Hui Xi, Zhuo-Wei Guo, Shu-Zhi Bai, Xiao-Bin Liu, Bao-Feng Yang, Guo-Qiang Chen.. The C-terminal 16 residues of band 3 are involved in arsenic trioxide-induced apoptosis.. Journal of Drug Targeting,2005;13(4):235-243
20、 Guohui Fu#,Tianying Wang, Baofeng Yang, Fengxiang Lv, Congning Shi, Lifeng Tian. . Purification and Characterization of the Human Erythrocyte Band3 Protein C-terminal Domain.. Biochemistry-US,2004;43(6):1633-1638.
21、Guohui Fu#, Hongqing Du, Hongtao Li. Lifeng Tian. . Expression and characterization of 55-kDa transmembrane domain of band 3 and glycophorin A.. Progress in natural Science,2002;12(3):227-231


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