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上海交通大学医学院研究生导师简介 沈旭

上海交通大学 免费考研网/2013-01-09

基本信息
导师姓名: 沈旭 专业代码: 100706
性别: 专业名称: 药理学
培养单位: 基础医学院 三级学科/
专业领域:
未设
导师类型: 博士生导师 专业学位导师:
联系方式: xshen@mail.shcnc.ac.cn 13917152160
研究方向 (点击浏览详细信息)
大分子-小分子(药物)相互作用的药物设计和发现研究
社会任职
华东理工大学 特聘教授;
“微生物与感染”杂志 常务编委
上海分子与细胞生物学学会 理事
中国药理学报 编委
“亚洲生物化学”杂志
科研项目
项目编号项目名称课题来源起止时间科研经费承担职责
2008ZXJ09014-006保密专项2008-10~~2010-12550.52万元课题负责人
90713046“基于天然活性分子LX0278为探针的胰岛素增敏新信号转导通路的发现国家自然科学基金2008-01~~2011-12240万元课题负责人
杰青30525024药物设计学国家自然科学基金2006-01~~2009-12160万元课题负责人
2005AA235030“成药性先导化合物发现的关键技术及其应用研究"863重大专项2005-01~~2005-12180万元课题负责人
2004CB518905基于功能基因调控网络的抗II型糖尿病药物发现国家重点基础研究规划(973计划)2004-10~~2009-09361.5万元子课题负责人
学术论文 (#为通讯作者,*为共同第一作者)

1、Tiancen Hu, Yu Zhang, Lianwei Li, Kuifeng Wang, Shuai Chen, Jing Chen, Jianping Ding, Hualiang Jiang*, and Xu Shen*#. “Two Adjacent Mutations on the Dimer Interface of SARS Coronovirus 3C-like Protease Result in Totally Different Conformation Changes in Crystal Structure.” . Virology,2009;388, 324-334
2、Zhang L, Liu W, Hu T, Du L, Luo C, Chen K, Shen X*#, Jiang HL. “Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) ”. J Biol Chem,2008;283, 5370-9
3、Hu T, Wu D, Chen J, Ding J, Jiang H*, Shen X*#. “The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis”. J Biol Chem,2008;283, 21284-93
4、Zhonghui Lin, Yu Zhang, Yinan Zhang, Hong Shen, Lihong Hu, Hualiang Jiang, Xu Shen*#. “Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism”. Biochem Pharm,2008;76,1251-1262
5、Shen H, Zhang Y, Ding H, Wang X, Chen L, Jiang H, Shen X*#. "Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter". Cell Physiol Biochem,2008;22, 1-14
6、Zou G, Gao Z, Wang J, Zhang Y, Ding H, Huang J, Chen L, Guo Y, Jiang H, Shen X*#. "Deoxyelephantopin inhibits cancer cell proliferation and functions as a selective partial agonist against PPARgamma". Biochem Pharmacol,2008;75, 1381-92
7、Lin Z, Shen H, Huang J, Chen S, Chen L, Chen J, Liu G, Jiang H, Shen X*#. "Butyl 4-(butyryloxy)benzoate functions as a new selective estrogen receptor beta agonist and induces GLUT4 expression in CHO-K1 cells". J Steroid Biochem Mol Biol,2008;110, 150-6
8、Wu D, Zhang L, Kong Y, Du J, Chen S, Chen J, Ding J, Jiang HL*, Shen X*#. 10.“Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori”. Proteins,2008;72, 1148-1160
9、Liang Zhang, Yunhua Kong, Dalei Wu, Haitao Zhang, Jian Wu, Jing Chen, Jianping Ding, Lihong Hu*, Hualiang Jiang and Xu Shen*. 15.“Three flavonoids targeting the ?-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay”. Protein Sci,2008;17, 1971-8
10、Sun T, Wang Q, Yu Z, Zhang Y, Guo Y, Chen K, Shen X*#, Jiang H. "Hyrtiosal, a PTP1B inhibitor from the marine sponge Hyrtios erectus, shows extensive cellular effects on PI3K/AKT activation, glucose transport, and TGFbeta/Smad2 signaling". ChemBioChem,2007;8, 187-93
11、Haibin Luo, Dalei Wu, Can Shen, Kaixian Chen, Xu Shen*#, and Hualiang Jiang*. “Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction”. Int. J. Biochem.istry & Cell Biology,2006;38, 589–599
12、Tanis Hogg, Krishna Nagarajan, Saskia Herzberg, Lili Chen, Xu Shen*#, Hualiang Jiang, Maria Wecke, Christoph Blohmke, Rolf Hilgenfeld,.and C. L. Schmidt. “Structural and functional characterization of falcipain-2, a hemoglobinase from the malarial parasite plasmodium falciparum”. Journal of Biological Chemistry,2006;281,25425-25437
13、Jian Zhang, Chenjing Li, Kaixian Chen, Weiliang Zhu, Xu Shen*#, Hualiang Jiang*. “Conformational transition pathway in the allosteric process of human glucokinase”. PNAS,2006;103 , 36, 13368–13373.
14、Ye F, Zhang ZS, Luo HB, Shen JH, Chen KX, Shen X*#, Jiang HL. "The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARgamma: bioassay with molecular modeling simulation". ChemBioChem,2006;7, 74-82
15、Fei Ye, Tao Sun, Haibin Luo, Hong Ding, Kaixian Chen, Xu Shen* and Hualiang Jiang”#. “Quantitative Characterization of 15-Deoxy-Delta(12,14)-Prostaglandin J2 in Regulating EGFP-Smad2 Translocation in CHO Cells Through PARγ/TGFβ/Smad2 Pathway”. Cell. Physiol. Biochem,2006;18, 143-150


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