上海交通大学医学院研究生导师简介周虎臣

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上海交通大学免费考研网/2013-01-09

基本信息

导师姓名:	周虎臣	专业代码:	100706
性别:	女	专业名称:	药理学
培养单位:	基础医学院	三级学科/ 专业领域:	未设
导师类型:	博士生导师	专业学位导师:
联系方式:	hczhou@sjtu.edu.cn 34206721 个人网页：http://pharm.sjtu.edu.cn/3-1.asp

研究方向 (点击浏览详细信息)

生物有机化学；化学生物学

社会任职

美国化学会(ACS) 会员

美国科学促进会(AAAS) 会员

上海药学会药物化学专业委员会委员

上海高校E-化学生物学研究院特聘研究员

J. Med. Chem., Eur. J. Med. Chem., MedChemComm, BMC, BMCL, FEBS Letter审稿人

科研项目

项目编号	项目名称	课题来源	起止时间	科研经费	承担职责
81222042	药物化学和化学生物学	国家自然科学基金优秀青年基金	2013-01~~2015-12	100万元	课题负责人
2012CB518000	重大心血管疾病相关GPCR新药物靶点的基础研究	国家重大科学研究计划	2012-01~~2016-12	30万元	课题参与人
YG2009MS01	利用小分子化合物SSMU11研究RARa降解的分子机制	医工（理）交叉研究基金	2009-06~~2011-06	5万元	课题参与人
2009CB918404	蛋白质翻译后修饰的发生与调控机制及其生理病理效应	重大科学研究计划973	2009-01~~2013-12	40万元	课题参与人
07SG15	蛋白质-蛋白质间相互作用的小分子干扰剂的设计与合成	上海教委曙光学者	2008-01~~2009-12	15万元	主要责任人
20702031	疟疾和血吸虫病的新药设计,合成及构效关系	自然科学基金	2008-01~~2010-12	20万元	主要责任人
07pj14095	锥虫病和血吸虫病治疗新药物的设计,合成及构效关系	上海科委浦江计划	2007-09~~2009-09	20万元	主要责任人
	抗感染药物的药物化学研究和计算机辅助药物设计	横向国际合作	2007-04~~2010-03	120万元	主要责任人

学术论文 (#为通讯作者,*为共同第一作者)

1、J. Zhang, H. Zhou#. The application of small molecule bioactive probes in the identification of cellular targets.. Yaoxue Xuebao,2012;47(1):299-306.
2、Z. Qiao, Q. Wang, F. Zhang, Z. Wang, T. Bowling, B. Nare, R. Jacobs, J. Zhang, D. Ding, Y. Liu, H. Zhou#. Chalcone-benzoxaborole hybrid molecules as potent antitrypanosomal agents.. J. Med. Chem.,2012;55(1):3553-3557.
3、C. Liu, Q. Yin, H. Zhou*, Y. Wu, J. Pu, L. Xia, W. Liu, X. Huang, T. Jiang, M. Wu, L. He, Y. Zhao, X. Wang, W. Xiao, H. Chen, Q. Zhao, A. Zhou, L. Wang, H. Sun, G. Chen. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.. Nature Chem. Biol.,2012;8(1):486-493.
4、Y. Zhao, Q. Wang, Q. Meng, D. Ding, H. Yang, G. Gao, D. Li, W. Zhu, H. Zhou#. Identification of Trypanosoma brucei leucyl-tRNA synthetase inhibitors by pharmacophore- and docking-based virtual screening and synthesis.. Bioorg. Med. Chem.,2012;20(1):1240-1250.
5、Y. Zhang, J. Plattner, Y. Freund, E. Easom, Y. Zhou, L. Ye, H. Zhou, D. Waterson, F. Gamo, L. Sanz, M. Ge, Z. Li, L. Li, H. Wang, H. Cui. Benzoxaborole antimalarial agents. 2. Discovery of fluoro-substituted 7-(2-carbozyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.. Bioorg. Med. Chem. Lett.,2012;22(1):1299-1307.
6、Z. Gu, C. Liu, S. Wu, M. Zhao, H. Xu, W. Liu, H. Zhou, G. Chen, Y. Wu . PU.1 directly regulates retinoic acid-induced expression of RIG-G in leukemia cells.. FEBS Lett.,2011;585(1):375-380.
7、D. Ding, Q. Meng, G. Gao, Y. Zhao, Q. Wang, B. Nare, R. Jacobs, F. Rock, M. Alley, J. Plattner, G. Chen, D. Li, H. Zhou#. Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.. J. Med. Chem.,2011;54(1):1276-1287.
8、P. Wu, Q. Meng, H. Zhou#. Synthesis of novel pyrrolo-benzoxaborole scaffold and its derivatization via Friedel-Crafts reaction catalyzed by anhydrous stannic chloride.. Chin. Chem. Lett.,2011;22(1):1411-1414.
9、Z. Qiao, W. Wang, L. Wang, D. Wen, Y. Zhao, Q. Wang, Q. Meng, G. Chen, Y. Wu, H. Zhou#. Design, synthesis, and biological evaluation of benzodiazepine-based SUMO-specific protease 1 inhibitors.. Bioorg. Med. Chem. Lett.,2011;21(1):6389-6392.
10、M. Wu, Q. Meng, M. Ge, L. Bai, H. Zhou#. 2,3,6-Trideoxy sugar nucleotides: synthesis and stability.. Tetrahedron Lett.,2011;52(1):5799-5801.
11、D. Ding, Y. Zhao, Q. Meng, D. Xie, B. Nare, D. Chen, C. Bacchi, N. Yarlett, Y. K. Zhang, V. Hernandez, Y. Xia, Y. Freund, M. Abdulla, K. H. Ang, J. Ratnam, J. H. McKerrow, R. T. Jacobs, H. Zhou#, J. J. Plattner. Discovery of novel benzoxaborole-based potent antitrypanosomal agents.. ACS Med. Chem. Lett.,2010;1, 165-169.
12、Y. Wu, H. Zhou, G. Chen. Molecular mechanisms of leukemia-associated protein degradation.. Front. Med. China,2010;4(1):363-370.
13、L. Ye, D. Ding, Y. Feng, D. Xie, P. Wu, H. Guo, Q. Meng, H. Zhou#. Convenient and versatile synthesis of formyl-substituted benzoxaboroles.. Tetrahedron,2009;65, 8738-8744
14、Q. Lu, F. M. Longo, H. Zhou, S. M. Massa, Y. Chen. Signaling through Rho GTPase pathway as viable drug target.. Curr. Med. Chem.,2009;16, 1355-1365.
15、T. Akama, S. J. Baker, Y. K. Zhang, V. Hernandez, H. Zhou, V. Sanders, Y. Freund, R. Kimura, K. R. Maples, J. J. Plattner. Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.. Bioorg. Med. Chem. Lett.,2009;19, 2129-2132.
16、W. Chen, T. Huang, X. He, Q. Meng, D. You, L. Bai, J. Li, M. Wu, R. Li, Z. Xie, H. Zhou, X. Zhou, H. Tan, Z. Deng. Charaterization of the polyoxin biosynthesis gene cluster from Streptomyces cacaoi and engineered production of polyoxin H.. J. Biol. Chem.,2009;284, 10627-10638.
17、Y. Zhou, Q. Meng, D. You, J. Li, S. Chen, D. Ding, X. Zhou, H. Zhou#, L. Bai, Z. Deng. Selective removal of aberrant extender units by a type II thioesterase for efficient FR-008/candicidin biosynthesis in streptomyces sp. strain FR-008.. Appl. Environ. Microbiol.,2008;74, 7235-7242.
18、F. L. Rock, W. Mao, A. Yaremchuk, M. Tukalo, T. Crepin, H. Zhou, Y. K. Zhang, V. Hernandez, T. Akama, S. J. Baker, J. J. Plattner, L. Shapiro, S. A. Martinis, S. J. Benkovic, S. Cusack, M. R. K. Alley. An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site.. Science,2007;316, 1759-1761.
19、S. J. Baker, Y. K. Zhang, T. Akama, A. Lau, H. Zhou, V. Hernandez, W. Mao, M. R. K. Alley, V. Sanders, J. J. Plattner. Discovery of a new boron-containing antifungal agent, 5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), for the potential treatment of onychomycosis.. J. Med. Chem.,2006;49, 4447-4450.
20、H. Zhou, L. Baldini, J. Hong, A. Wilson, A. D. Hamilton. Pattern-recognition of proteins based on an array of functionalized porphyrins. J. Am. Chem. Soc.,2006;128, 2421-2425.
21、H. Zhou, L. Baldini, E. Ennis, R. Jain, S. M. Sebti, D. A. Wang, M. A. Blaskovich, A. D. Hamilton. Structure-Activity studies of a library of potent calix[4]arene based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Org. Biomol. Chem.,2006;4, 2376-2386.