摘要/Abstract

一氧化碳(CO)是人体内重要的气体信号分子, 在多种重要的生理病理代谢活动中起着关键性的调控作用, 被认为是具有广泛医学应用前景的药物活性分子. CO生理学效应与其浓度、空间分布密切相关. 因此, 生物体内特异检测CO以及可控性供给CO对于充分理解并有效利用其生理病理功能具有十分重要的意义. 荧光检测和光控释放因其无侵入性、时空可控等优势被广泛地运用于细胞、组织及活体内生物活性小分子的示踪和运输. 鉴于此, 本综述总结了近年来CO有机荧光探针和光控释放剂的研究进展, 着重阐述了其识别机理、释放机制和生物应用, 并展望了CO荧光探针和光控释放剂的发展趋势和应用前景.
关键词: 一氧化碳, 荧光探针, 光控释放
Carbon monoxide (CO), an extremely important gasotransmitter, plays a critical role in a variety of physiological and pathological events, thus having been considered as a pharmaceutical activity compound with broad medical application. The physiological effects of CO are determined by its dose and spatial location. Therefore, the specific recognition of CO and its controllable supplying are of great significance for understanding and effectively utilizing its physiological and pathological effects. Fluorescence detection and photocontrolled releasing have been widely applied to track and carry active molecules in cells, tissues and in vivo in view of their unique spatiotemporal controllability and noninvasive capacity. Herein, the research progress of CO organic fluorescent probes and photocontrolled releasers in recent years is reviewed, focusing on their recognition mechanism, release mechanism and biological applications. Finally, the application prospects and challenges are discussed.
Key words: carbon monoxide, fluorescent probe, photocontrolled releasing


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