摘要/Abstract

P-手性膦氧类化合物在药物化学、有机合成化学、生命及材料科学等领域具有重要的应用价值和潜能，是一类受到广泛关注的优势结构.近年来，针对这一结构的不对称催化构建取得了显著进展.本综述旨在从三级膦氧化物的去对称化反应和（动态）动力学拆分反应以及二级膦氧化物参与的不对称反应三种策略出发，介绍目前用于构建P-手性膦氧化物的不对称催化合成方法及最新研究进展.藉此也对这些反应的机理及其优势与不足之处进行简要讨论，为从事有机合成和有机膦化学相关的研究人员提供一些有益参考和借鉴.
关键词: P-手性膦氧化物, 不对称催化合成, 去对称化反应, (动态)动力学拆分, 三级膦氧化物, 二级膦氧化物
P-Chiral phosphine oxides are a class of privileged structures, which have important applications in the field of medicinal chemistry, organic synthesis, life and material science. Recent years have witnessed significant progress in the catalytic asymmetric construction of such scaffolds. These advances are summarized in this review according to the following three major strategies:desymmetrization of prochiral tertiary phosphine oxides, (dynamic) kinetic resolution of tertiary phosphine oxides, and catalytic asymmetric reactions involving secondary phosphine oxides, and discusses the possible reaction mechanism, the advantage and disadvantage of each type of reactions, which would provide reference and inspiration for the researchers engaged in organic synthesis and organic phosphorus chemistry.
Key words: P-chiral phosphine oxide, catalytic asymmetric synthesis, desymmetrization, (dynamic) kinetic resolution, tertiary phosphine oxide, secondary phosphine oxide


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