摘要/Abstract
随着纳米技术的发展及其向医学领域的渗透，纳米技术为肿瘤的治疗开辟了新的途径，构建有效的纳米载体体系对于肿瘤的治疗具有十分重要的意义.本工作报道了一种铋纳米粒子嵌入ZIF-8的纳米材料Bi@ZIF-8@TPZ（BZT），联合近红外二区（NIR-II）的光热治疗与化疗，达到了良好的治疗效果.BZT纳米材料高效地装载了抗癌药物替拉扎明（TPZ），同时嵌入的铋纳米点使得该纳米材料具有NIR-II光热的能力.因ZIF-8具有良好的pH响应能力，所以在酸性和光照条件下能实现药物的可控释放，实现了化疗与NIR-II光热治疗的协同治疗，使得BZT纳米材料在临床上具有很高的应用价值.
关键词: 纳米粒子, 替拉扎明, 近红外二区, 协同治疗
With the development of nanotechnology and its penetration into the field of medicine, nanotechnology has opened a new way for the treatment of tumors. Building an effective nanocarrier system is significant for the treatment of tumors. Compared with the traditional drug therapy, the drug which uses the nanomaterial as the carrier can greatly improve the treatment effect of the medicine and the side effect caused by the medicine in the in-vivo circulation process is extremely reduced simultaneously. At the same time, due to the protective effect of the carrier, the stability of the drug can be improved obviously. In this paper, we report a composite nanomaterial Bi@ZIF-8@TPZ (BZT) which is the formation of Bi nanoparticles and tirapazamine (TPZ) embedded in ZIF-8, this novel nanomaterial combines chemotherapy with photothermal therapy in the second near-infrared region (NIR-II), and achieves a good therapeutic effect. First, we prepared a Bi@ZIF-8 (BZ) nanoparticle by a simple one-step reduction method. The morphology and microstructure of the nanoparticle were analyzed by transmission electron microscopy (TEM) and X-ray diffraction (XRD). Next, the anticancer drug tirapazamine (TPZ) was efficiently loaded into the BZ nanomaterial by physical mixing. The UV absorption spectrum proved that it could be successfully loaded, and the loading efficiency (LE) was 30%. Furthermore, the embedded Bi nanoparticles make the composite nanomaterials have good photothermal properties in NIR-II area, and the photothermal conversion efficiency is about 31.75%. Because ZIF-8 has a good pH response ability, the material can achieve controllable drug release under weak acid (pH=5.5) and light conditions. In vitro results show that BZ loaded with the chemotherapeutic drug TPZ can achieve a good therapeutic effect. The composite materials reported in this article realize the synergistic treatment of chemotherapy and NIR-II photothermal treatment, which makes it highly clinically useful.
Key words: nanoparticle, tirapazamine, second near-infrared window (NIR-II), synergistic treatment
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