摘要/Abstract

1,3,5-三嗪烷是一类重要的合成子, 可看成是甲醛亚胺的等价物, 参与各类含氮杂环骨架的构建. 近年来, 1,3,5-三嗪烷在含氮杂环化合物的构建中引起了越来越多的关注. 基于此, 系统综述了1,3,5-三嗪烷作为双原子、三原子以及四原子合成子参与[2+n], [3+n], [4+n]环加成反应构建含氮杂环化合物的反应研究进展, 总结了其在环加成、杂环化学以及药物化学中的应用, 并展望了基于1,3,5-三嗪烷参与构建含氮杂环骨架及其应用的未来发展趋势.
关键词: 1,3,5-三嗪烷, 含氮杂环, 合成子, 环加成反应, 药物化学
1,3,5-Triazinanes are an important class of synthons, which could be regarded as the equivalent of formaldehyde imines in constructing various nitrogen-containing heterocyclic skeletons. In recent years, 1,3,5-triazinanes have attracted much attention in the construction of nitrogen-containing heterocyclic compounds. Based on this, the participation of 1,3,5-triazinanes as diatomic, triatomic and four-atom synthons in [2+n], [3+n], [4+n] cycloaddition reactions to construct nitrogen-containing heterocyclic compounds is systematically summarized. Its applications in cycloaddition, heterocyclic chemistry and pharmaceutical chemistry are also summarized. Moreover, the development of 1,3,5-triazinanes in the construction of nitrogen-containing heterocyclic skeletons and their future applications are also prospected.
Key words: 1,3,5-triazinane, nitrogen-containing heterocycle, synthon, cycloaddition reaction, pharmaceutical chemistry


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