摘要/Abstract

在氧气氛围中, 以2-芳基吲哚和N-乙酰基烯胺为原料, 实现了一锅法快速构建三环吲哚啉稠环骨架化合物. 该方法具有原料易得、操作简便、区域和非对映选择性较高以及环境友好等特点. 机理研究表明, 反应首先发生氧化去芳构化, 随后与烯酰胺进行[3+2]环化反应.
关键词: 钴催化, 氧化去芳构化, 环化反应, 吲哚, 烯酰胺
An one-pot reaction for the rapid construction of tricyclic fused indoline frameworks from 2-aryl indoles and N-acetyl enamides under oxygen atmosphere has been developed. The notable features of this method involve easy availability of starting materials, simple manipulation, good regio- and diastereo-selectivity, as well as environmentally friendly conditions. Mechanistic studies indicated that this reaction proceeds via oxidative dearomatization and subsequent [3+2] annulation with enamides.
Key words: cobalt-catalysis, oxidative dearomatization, annulation, indoles, enamides


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