摘要/Abstract

β-内酰胺类化合物是具有高生物活性及高应用价值的抗生素, 如何高效高选择性地设计、合成该类化合物一直是有机化学研究的热点问题. 由于其环状结构中具有羰基结构, 利用一氧化碳(CO)作为羰源与底物分子发生羰基化反应也发展成为合成β-内酰胺的有效方法. 通过该方法可以一步高效合成结构多样性且新颖的β-内酰胺化合物. 综述了近年来通过不同底物分子与CO发生羰基化反应构建β-内酰胺的研究进展, 并且对该方法存在的问题以及未来发展方向进行了展望.
关键词: β-内酰胺, 一氧化碳, 羰基化, 氮杂环丙烷, 烯酮
β-Lactam compounds are antibiotics with high biological activity and high application value. Design and synthesis of β-lactams with high efficiency and high selectivity have always been a hot issue in organic chemistry. Because of the carbonyl group in the ring structure, the carbonylation reaction between substrate and carbon monoxide (CO) has also developed into a new method for synthesis of β-lactams, which can be used to synthesize novel and diverse structures in one step. In this paper, the carbonylation of different substrates with CO to synthesize β-lactams in recent years is reviewed, and the existing problems and future development of this strategy are prospected.
Key words: β-lactams, carbon monoxide, carbonylation, aziridine, ketene


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