摘要/Abstract
报道了4-取代-1-磺酰基-1,2,3-三氮唑在绿色溶剂中的催化水解反应, 以1 mol%硫酸铜作为催化剂, 在水/ PEG-400混合溶剂中以较高的收率高效合成了4-取代-2H-1,2,3-三氮唑. 该方法为制备2H-1,2,3-三氮唑类化合物提供了一种绿色、简单、有效的方法. 此外, 还用一锅法对2H-1,2,3-三氮唑进行了溴化、芳基化、烷基化的探索, 效果良好.
关键词: 2H-1,2,3-三氮唑, 硫酸铜, 三唑衍生物, 绿色溶剂
The hydrolysis of 4-substituted 1-sulfonyl-1,2,3-triazoles induced by a catalytic amount of copper sulfate in the green solvent of H2O/PEG-400 was reported, providing a wide range of 4-substituted-2H-1,2,3-triazoles in excellent yields. The approach provides a green, simple and effective method for the preparation of 2H-1,2,3-triazole compounds. Bromination, arylation, and alkylation on 2H-1,2,3-triazoles by the one-pot method were also explored.
Key words: 2H-1,2,3-triazole, copper sulfate, triazole derivative, green solvent
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