摘要/Abstract
中环(8~11元环)与大环(12元环及以上)是药物和天然产物中非常重要的结构并广泛应用于药物合成、有机化学以及其他领域. 科研工作者一直致力于开发更加简单、绿色、高效的合成中环大环的方法. 归纳并总结近五年来最新的通过扩环和环化反应方法合成中环大环化合物的研究现状和进展, 并对其未来的发展方向进行了总结和展望.
关键词: 中环化合物, 大环化合物, 扩环反应, 环化反应
Medium-sized rings (8~11 membered ring) and macrocycles (12-membered rings and above) are extremely important parts of drug and natural products. Meanwhile, they are widely used in the field of medicinal chemistry, organic chemistry and other fields. Developing simple, green and efficient protocol to synthesize medium-sized rings and macrocycles has attracted great interests from chemists in the recent years. The latest ring expansion/cyclization reaction in the synthesis of medium-sized ring and macrocyclic compounds in the past five years is reviewed, and the prospect of their future and development is also outlined.
Key words: medium-sized ring, macrocycle, ring expansion reaction, cyclization
PDF全文下载地址:
点我下载PDF
