摘要/Abstract

金鸡纳硅醚衍生物用于有机催化不同吲哚和靛红的不对称Friedel-Crafts反应. 筛选出最佳的催化剂体系, 以78%~96%的产率和最高达99%的对映选择性获得了手性3-羟基-2-吲哚酮. 拓宽了该反应的催化剂类型和底物范围.
关键词: 金鸡纳硅醚衍生物, 有机催化, 靛红, 吲哚, 不对称Friedel-Crafts反应
A series of cinchona alkaloid silyl ether derivatives have been used to catalyze the enantioselective Friedel-Crafts reaction of indoles with isatins. The resulting 3-hydroxy-2-oxindoles were obtained in good yields (78%~96%) with high enantioselectivities (up to 99% ee). The catalyst type and the substrate scope were broadened in this methodology.
Key words: cinchona alkaloid silyl ether, organocatalysis, isatin, indole, enantioselective Friedel-Crafts reaction


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