摘要/Abstract

在温和的条件下, 利用3-乙酰基吲哚与吲哚的加成/取代串联反应, 高效地合成了一系列高度拥挤的四取代三吲哚甲烷. 该方法通过在3-乙酰基吲哚的氮原子上引入吸电子基团, 提高了3-乙酰基吲哚的反应活性, 具有原料廉价易得、底物适用性广、操作简便等优点.
关键词: 吲哚, 三吲哚甲烷, 串联反应
An efficient one-pot synthesis of highly crowded tetrasubstituted tri(indolyl)methanes has been achieved through the addition/substitution sequence of 3-acetylindoles and indoles under mild conditions. The key to the success was improving the reactivity of 3-acetylindoles by rationally installing the N-protecting groups. The salient features including easily accessible and low-cost starting materials, board substrate scope, simple operation and structurally useful products make this approach particularly attractive.
Key words: indole, tri(indolyl)methane, cascade reaction


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