摘要/Abstract

通过金催化选择性氧化1,3-共轭炔基炔酰胺, 为4-羰基丁-2-炔酰胺化合物的合成提供了一种新的方法. 这种含有活化的不饱和炔烃的1,4-双羰基化合物是有机化学中一种重要的合成子. 利用该金催化氧化方法, 可以高度选择性地对共轭炔烃的1,4-位进行氧化得到2-炔-4-羰基丁酰胺化合物, 而不是生成较为常见的1,2-双羰基化合物. 在该选择性氧化的条件下, 可以以较高的收率得到一系列4-羰基丁-2-炔酰胺化合物.
关键词: 共轭炔酰胺, 金催化, 选择性氧化, 双羰基化合物
A gold-catalyzed selective oxidation of 1,3-diynamides has been developed to provide a novel approach to 4-oxo-but-2-ynamides. The products possess activated C—C triple bond, and often serve as versatile building blocks in synthetic community. This gold-catalyzed selective oxidation of 1,3-diynamides to provide 4-oxo-but-2-ynamides is noteworthy, since the traditional 1,2-dicarbonyl type products were not observed. Under standard conditions, a range of 4-oxo-but-2-yna- mide derivatives were obtained in moderate to high yields.
Key words: 3-diynamides, gold catalysis, selective oxidation, dicarbonyl compounds


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