摘要/Abstract
肿瘤的发病率呈逐年上升趋势,已成为威胁人类健康的第一大疾病.光疗(光动力疗法和光热疗法)作为一类新型的肿瘤治疗方式,具有创伤小、治疗周期短、毒副作用低、选择性好、无抗药性和免疫抑制等优点,受到了研究人员的广泛关注,并已被逐步应用于临床.作为光疗中至关重要的决定性因素,光敏剂和光热试剂的研究受到越来越多的重视.吡咯并吡咯二酮具有平面性好、电子亲和势强、合成简单、结构易修饰及摩尔吸光系数高等优点,是一种优异的光敏剂和光热试剂.从吡咯并吡咯二酮的结构改造、结构与性能关系、光疗作用机理等方面对近年来吡咯并吡咯二酮类光敏剂和光热试剂的研究现状进行了综述,并对其发展趋势进行了展望.
关键词: 吡咯并吡咯二酮, 光动力治疗, 光热治疗, 联合治疗
Cancer has become one of the major threats to human health in modern society. Phototherapy including photodynamic therapy (PDT) and photothermal therapy (PTT), as a new type of tumor treatment, has received more and more attentions due to its high spatiotemporal precision, noninvasive nature, controllability, low toxicity and repeatable treatment without initial resistance. It is important to obtain a highly efficient and ideal photosensitizer for reactive oxygen species (ROS) generation for PDT. Photothermal agents with high photothermal conversion efficiency are also in urgent need for PTT. Diketopyrrolopyrrole (DPP) is an excellent type of photosensitizer and photothermal reagent because of its good structural planarity, strong electron affinity, simple synthesis, easy structure modification and high molar absorption coefficient. The research progress of DPP-based photosensitizers and photothermal agents in recent year, including structural modification of DPP, the structure-activity relationship, the mechanism of phototherapy and some representative examples is summarized. Finally, a perspective on the future development of phototherapy based on DPP is presented.
Key words: diketopyrrolopyrrole, photodynamic therapy, photothermal therapy, combined therapy
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