摘要/Abstract
从容易获得且便宜的原材料出发，通过简单的一锅式组装方法合成了一种新的P，O-型吲哚基膦配体，并将其用于钯催化的芳基氯Suzuki-Miyaura交叉偶联反应，结果显示配体上的“取代基”能促进该反应的活性，其钯催化剂载量可降至0.01 mol%.
关键词: 钯, 配体设计, 交叉偶联, 膦, P,O-型配体
A series of P,O-type indolylphosphine ligands with different substituted variants have been synthesized by a simple one-pot protocol from readily available and inexpensive materials. These ligands show "substituent effect" with respected to the efficacy in promoting palladium-catalyzed Suzuki-Miyaura cross-coupling of aryl chlorides. This new Pd/L1 catalyst system particularly allows the catalyst loading reaching the level of 0.01 mol% Pd.
Key words: palladium, ligand design, cross-coupling, phosphine, P,O-ligand
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