摘要/Abstract

自由基反应具有高效迅捷、选择性优良及官能团容忍性好等优点，是构建有机化合物的有效策略和方式之一.路易斯碱-硼自由基具有独特的结构和反应性能，在有机合成中表现出了良好的应用潜力.总结了我们课题组在路易斯碱-硼自由基促进的有机分子转化方面取得的一些进展.研究成果主要包括以下三个方面：路易斯碱-硼自由基促进的硼化反应、路易斯碱-硼自由基催化反应，以及路易斯碱-硼自由基引发的还原反应.这些反应具有条件温和，官能团容忍性好，产率高，化学、区域选择性好等优点.
关键词: 路易斯碱-硼自由基, 自由基硼化反应, 自由基催化反应, 自由基还原反应, 自由基化学
Free radical reactions represent an efficient and significant tool to construct organic molecules by taking advantages of the high-efficiency, remarkable selectivity and good functional groups tolerance. Lewis-base boryl radicals are a class of species that possess unique structures and chemical reactivity, and a variety of synthetic applications have been developed. This account summarizes the research advances in this research field mainly contributed by our group. The results include Lewis-based boryl radicals enabled borylation reactions, Lewis-based boryl radicals-catalyzed new reactions, and Lewis-based boryl radicals promoted reduction reactions. These reactions feature mild reaction conditions, good functional groups compatibility, high yields, and excellent chemo-, regio-, and stereo-selectivities.
Key words: Lewis-base boryl radicals, radical borylation reactions, radical catalysis, radical reduction reactions, free radical chemistry


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