删除或更新信息,请邮件至freekaoyan#163.com(#换成@)

合成2,5-二芳基噻唑衍生物的新方法

本站小编 Free考研考试/2022-02-14

摘要/Abstract



噻唑环作为一类重要的五元芳香杂环,其衍生物具有多种生物活性,被广泛应用在医药方面.以价廉易得的不同取代苯甲酸为原料,经酰化反应、硫代反应、环合反应和Heck反应合成了2,5-二芳基噻唑衍生物.重点在于优化Heck反应的条件,进行可能反应机理的探讨.该方法具有反应条件温和、操作简单及底物的普适性良好等优点,为2,5-二芳基取代噻唑类化合物的合成提供了新的方向.
关键词: 2,5-二芳基噻唑, Heck反应, 有机合成
Thiazole ring is an important five-membered aromatic heterocyclic ring, and its derivatives have various biological activities and are widely used in medicine. The synthesis of 2,5-diarylthiazole derivatives by acylation, thiolation, cyclization and Heck reaction using inexpensive and readily available substituted benzoic acid as raw materials was developed. The key point was to optimize the Heck reaction conditions and explore the possible reaction mechanism. The method has mild reaction conditions, simple operation, and good substrate universality, which provides a new direction for the synthesis of 2,5-diaryl substituted thiazoles.
Key words: 2,5-diarylthiazole, Heck reaction, organic synthesis


PDF全文下载地址:

点我下载PDF
鐎殿喒鍋撻梺顐g濠€鎵博濮楃P闁挎稒鐭粩瀛樼▔閸モ晩娼氶柤鏉垮暟閻栫儤绋夐幘鑼懝閻犲洦宕橀~瀣紣閹达附顓瑰〒姘虫硶濠€鍛存晬鐏炲墽妲ㄩ柡鍫厸缁楀宕氭0浣侯伇闁告帒妫濋幐鍫曟晬娴h櫣鍗滈悗鐢垫嚀閸ㄦ繄绮诲Δ瀣<
547闁圭鍋撻梻鍕╁灪閻楀酣鎳撻崘顏嗗煛闁兼澘鍟畷锟�1130缂佸绉电€垫氨鈧纰嶉弳鈧柡澶嬪姉濞堟垿宕¢崘褏绋囩紒澶婄Ч閸樸倖绺藉Δ鍜佹毌閹煎瓨鎸堕埀顑挎祰椤锛愰幋顖滅婵炴垹鏁稿ú濠囨嚐鏉堫偒鍤旈柕鍡曡兌缁€趁规惔娑掑亾娴g晫妲堥柛鎺撴偠閳ь兛绶氶崳楣冩懚瀹ュ啠鍋撴担鐑樺€炵€规悶鍎埀顑胯兌椤撴悂鎮堕崱鎰ㄥ亾娴f亽浠﹀ù鍏煎搸閳ь兛娴囬崒銊﹀濮樸儮鍋撴担瑙勬畬闁煎弶褰冪缓楣冩偠閸℃劏鍋撴担鐤幀闁哄倸娲㈤埀顑挎祰婢规捇寮甸妯峰亾娴h鐓€闂傚倽顔婄槐鍫曞箻椤撴壕鍋撴担鍦€婇悗娑宠礋閳ь兛绀佺亸鎵偓娑宠礋閳ь兛娴囬鍝ョ不濡や焦绨氶柕鍡曠瀹稿宕g仦鍌楀亾娴e憡鍕鹃柣鐐叉閳ь兛鐒﹂弬鍌氣柦濮瑰洠鍋撴担鍛婃噸閻庢冻璐熼埀顑挎缂嶅鎳栭懠顒冾潶缂佹冻鎷�28缂侇偉顕ч鐔虹矓閹搭垳纾�
相关话题/医药 优化 生物 噻唑 衍生物