摘要/Abstract

受贻贝粘附蛋白启发而产生的3，4-二羟基苯丙氨酸（DOPA）衍生物引起了人们对生物材料和医疗器械的功能化涂层产生广泛兴趣.芴甲氧羰酰基-3，4-二羟基缩丙酮-L-苯丙氨酸[Fmoc-DOPA（acetonide）-OH]是贻贝粘附蛋白和多肽的固相合成关键原料.然而，现有的Fmoc-DOPA（acetonide）-OH的合成方法步骤繁琐、成本高，使其实际应用受到极大阻碍.本工作报道的两步法策略制备Fmoc-DOPA（acetonide）-OH，是一种简单且经济高效的合成方法，具有广阔的应用前景.
关键词: 贻贝粘附蛋白, 3,4-二羟基苯丙氨酸(DOPA), Fmoc-DOPA(acetonide)-OH, 简单高效合成
3,4-Dihydroxyphenylalanine (DOPA) derivatives inspired by mussels have attracted broad interest in functional coatings of biomaterials and biomedical devices. Fmoc-DOPA(acetonide)-OH is the key precursor for solid-phase synthesis of adhesive mussel proteins and peptides. However, existing synthesis methods of Fmoc-DOPA(acetonide)-OH were tedious and costly which greatly hindered its practical application. Herein, a simple two-step strategy for preparing Fmoc-DOPA-(acetonide)-OH is reported, which is a simple and cost-effective synthesis method with broad application prospects.
Key words: mussel adhesion protein, 3,4-dihydroxyphenylalanine (DOPA), Fmoc-DOPA(acetonide)-OH, simple and efficient synthesis


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