摘要/Abstract

Buchwald-Hartwig偶联反应可用于嘧啶-2-胺的修饰.由于嘧啶-2-胺结构在药物中广泛存在，该反应有重要的工业应用价值.聚苯胺负载铜催化剂可由苯胺在铜盐存在下氧化聚合来合成，该催化剂可催化嘧啶-2-胺的Buchwald-Hartwig偶联反应.由于聚苯胺载体上氮本身就具有配位性能，该反应无需添加额外配体，即可以较高转化数（TON）催化反应.作为非均相催化剂，聚苯胺负载铜可回收利用，从而显著降低催化剂成本，符合工业应用需求.
关键词: 聚苯胺, 铜, 催化, Buchwald-Hartwig偶联, 无配体
Buchwald-Hartwig couplings can modify the pyrimidin-2-amines. Since the pyrimidin-2-amine structures widely exist in medicines, the reaction is of significant industrial application values. The polyaniline-supported copper catalyst (Cu@PANI) was synthesized via the oxidative polymerization of aniline in the presence of copper salt and it could catalyze the Buchwald-Hartwig couplings of pyrimidin-2-amines. Since the nitrogen in polyaniline could well coordinate with copper, the reaction did not require additional ligands and occurred at relatively high catalyst turnover numbers (TONs). As a heterogeneous catalyst, Cu@PANI could be recycled and reused to reduce the cost of catalyst, and meet the requirements of industrial application.
Key words: polyaniline, copper, catalysis, Buchwald-Hartwig coupling, ligand-free


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