摘要/Abstract

开发了一种鸟巢烷型二萜类天然产物关键二环[5/6]中间体的合成策略，该策略涉及亲核取代反应、自由基关环反应、Johnson-Claisen重排和格氏加成等一系列反应，并对反应条件进行优化.该路线具有高效、简洁的优点，在此类天然产物的全合成中有较大的应用潜力.
关键词: 鸟巢烷型二萜, 天然产物, 亲核取代, Claisen重排
A synthetic plan of bicyclo[5/6] key intermediate of cyathane is reported. All the involved reactions, such as nucleophilic substitution reaction, radical ring-closing reaction, Johnson-Claisen rearrangement and Grignard addition, were optimized for higher yields. The procedure provides a simple and efficient method for the synthesis of bicyclo-key intermediate of cyathane. It is expected to have wide applications in the synthesis of cyathane.
Key words: cyathane diterpenes, natural product, nucleophilic substitution, Claisen rearrangement


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