摘要/Abstract

3-（噁唑-5-基）吲哚类天然产物如Pimprinine，Streptochlorin等，广泛存在于海洋微生物中，因其具有多样的生物活性，在医药和农药领域中很有研究潜力.3-（噁唑-5-基）吲哚类天然产物的合成方法有很多研究报道，在吲哚结构上构建噁唑环是合成此类天然产物的关键.总结了已报道的3-（噁唑-5-基）吲哚类天然产物的生物活性，并对构建3-（噁唑-5-基）吲哚骨架的合成方法及部分主要反应机理进行了综述，探讨了3-（噁唑-5-基）吲哚类骨架作为一种优势活性结构在未来的应用前景.
关键词: 3-(噁唑-5-基)吲哚, 天然产物, 生物活性, 合成, 综述
3-(5-Oxazolyl)indole-type natural products such as pimprinine and streptochlorin, widely exist in marine microorganism, because of their diverse biological activity, 3-(5-oxazolyl)indoles show good research and development potential in the field of medicine and pesticide. Numerous studies have been performed to synthesize 3-(5-oxazolyl)indole-type natural products, in which the construction of indole ring and oxazole ring is the most important part. In this paper, the reported natural products with 3-(5-oxazolyl)indole skeleton structure and their biological activities are summarized, and the synthetic methods for 3-(5-oxazolyl)indole skeleton and some of their mechanism are also reviewed. The application prospect of 3-(5-oxazol-yl)indole as a dominant active structure in the future was discussed.
Key words: 3-(5-oxazolyl)indole, natural products, biological activities, synthesis, review


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