摘要/Abstract

从海洋真菌赤褐炭团菌（Hypoxylon rubiginosum）FS521中分离纯化得到17个聚酮类化合物，分别鉴定为4-乙酰氧基-8-甲氧基-3，4-二氢萘-1（2H）-酮（1）、4，8-二甲氧基-1-萘酚（2）、1'-羟基-4'，8，8'-三甲氧基[2，2']联萘-1，4-二酮（3）、3，6-dimethyl-atromentin（4）、4-羟基-8-甲氧基-3，4-二氢萘-1（2H）-酮（5）、regiolone（6）、methylsclerone（7）、5-methylmellein（8）、3，5-二甲基-8-甲氧基-3，4-二羟基异香豆素（9）、9-甲氧基萘（10）、1，8-二甲氧基萘（11）、8-甲氧基-1-萘醇（12）、7-甲氧基-3-甲基异苯并呋喃（13）、3-甲基-4-羟基苯乙酸（14）、nodulisporipyrone A（15）、nodulisporipyrone B（16）、3，4-二甲氧基-乙酰苯乙醇（17）.其中化合物1为新化合物，化合物2和3为新天然产物，新化合物的结构通过HRESIMS，1D NMR和2D NMR等光谱技术确定.此外，对分离所得的化合物1～4进行了体外细胞毒活性测试，结果表明化合物3对SF-268、MCF-7、HepG-2、A549有较强的细胞毒活性，其IC₅₀值分别为1.85、3.21、2.53、5.09 mmol·L^-1.
关键词: 海洋真菌, 赤褐炭团菌, 细胞毒活性, 聚酮
One new compound, named hypoxone A (1), together with two new natural products 4,8-dimethoxy-1-naphthol (2) and 1'-hydroxy-4',8,8'-trimethoxy[2,2']binaphthalenyl-1,4-dione (3), and fourteen known derivatives 4~17 were isolated from the broth extract of the marine fungus Hypoxylon rubiginosum FS521, which was isolated from a deep-sea sediment sample. Their structures were elucidated by interpretation of spectroscopic analysis and comparison with previously published data for the known ones. Moreover, compounds 1~4 were evaluated for their in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines, and compound 3 exhibited potent cytotoxic activity with IC₅₀ values of 1.85, 3.21, 2.53, and 5.09 mmol·L^-1, respectively.
Key words: marine fungus, Hypoxylon rubiginosum, cytotoxicity, polyketides


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