摘要/Abstract

具有光学活性的1，3-氨基醇既是有机化学中重要的合成砌块，也是众多生物活性分子的核心结构，因此不对称合成1，3-氨基醇一直是合成领域的一个热点.从aldol缩合或azo-aldol缩合合成，过渡金属催化C—H键活化、氨化合成，氮杂环的开环-加成合成，[3+2]偶极环加成反应等方面综述了近年来所发展的1，3-氨基醇的合成方法及进展.
关键词: 1,3-氨基醇, 不对称合成, 催化剂
Optically pure 1,3-amino alcohol is not only the important synthon in organic synthesis, but also the core structure of numerous bioactive molecule. As a result, the formation of 1,3-amino alcohols occupies a hot resarch topic in asymmetric synthesis. This review symmarizes several types of frequently-used methods and progress on synthesizing 1,3-amino alcohols:aldol or azo-aldol condensation synthesis, transition metal catalyzed C-H activation and amination synthesis, ring-opening and addition of azocyclic compounds, and[3+2] dipolar-cycloaddition reaction etc.
Key words: 1,3-amino alcohol, asymmetric synthesis, catalyst


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