摘要/Abstract

胺基化合物在有机化学、药物化学和功能性材料领域中具有广泛的应用，C—N键的高效构筑具有重要的研究意义.传统的胺化反应构筑C—N键需要对底物进行预官能团化，并且不可避免地生成定量的卤代物副产物，而C—H胺化反应直接以碳氢化合物为原料，反应具有“步骤”及“原子”经济性高的优点，符合绿色化学理念.过渡金属钴具有低毒、廉价的优势，作为C—H胺化反应的催化剂展示了其独特的催化特性，吸引了化学家们的关注.主要总结近年来钴催化C—H胺化反应的研究进展，同时对该研究领域所面临的挑战和发展前景进行总结和展望.
关键词: 钴催化, C—H胺化, 胺基化合物
Amino compounds have a wide range of applications in the fields of organic chemistry, medicinal chemistry and functional materials. The efficient construction of C-N bonds has important research significance. Conventional amination reactions to construct C-N bonds require pre-functionalization of the substrate and inevitably produce quantitative halogenate by-products. The C-H amination reaction is directly based on hydrocarbons. The reaction has the advantages of "step" and "atomic" economy, in line with the green chemistry concept. Transition metal cobalt has the advantage of low toxicity and low cost. As a catalyst for C-H amination reaction, it exhibits its unique catalytic properties and attracts the attention of chemists. The research progress of cobalt-catalyzed C-H amination in recent years is summarized. At the same time, the challenges and development prospects of the research field are summarized and forecasted.
Key words: cobalt catalysis, C-H amination, amino compound


PDF全文下载地址:

点我下载PDF