摘要/Abstract
铜催化Ullmann型C-N偶联反应是高效专一构建C-N键最重要的方法之一.水作为绿色清洁溶剂被广泛用于各种有机反应.按照配体结构特点，对配体促进的水介质或纯水相中，铜催化C-N交叉偶联反应研究进展做了全面的归纳，配体类型包括二胺类、酰肼类、邻菲罗啉类、糖类、吡啶-N-氧化物类、喹啉类、肟类和salen等.另外，对于无配体条件下，水介质或纯水相中铜催化C-N偶联反应也进行了综述.
关键词: 配体促进, 铜催化, 水介质/纯水, C-N交叉偶联
Copper-catalyzed Ullmann-type C-N coupling reaction is one of the most effective methods to construct the C-N bonds. Water, as green and clean solvent, has been successfully employed in various organic reactions. According to the structure of ligands, the progress of ligand-assisted copper-catalyzed C-N cross-coupling reaction in aqueous media or pure water is summarized comprehensively, and the ligands include diamines, hydrazides, phenanthrolines, carbohydrates, pyridine-N-oxides, quinolines, oximes and salen. In addition, ligand-free copper-catalyzed C-N coupling reactions in aquous media or pure water are also reviewed.
Key words: ligand-assisted, copper catalyst, aqueous media/pure water, C-N cross-coupling
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