摘要/Abstract
在醋酸铜/铜催化体系作用下, 以醛、2,2-亚戊基-1,3-二噁烷-4,6-二酮和芳基乙炔为原料, 发生包含Knoevenagel缩合与共轭加成反应的多组分反应, 有效地合成了12种5-(1-苯基-3-苯基丙基-2-炔基)-2,2-亚戊基-1,3-二噁烷-4,6-二酮衍生物. 该工艺具有收率高(65%~88%)、反应温和、操作简单及过量铜粉还能回收利用等优点.
关键词: 多组分反应, 醋酸铜/铜, 2,2-亚戊基-1,3-二噁烷-4,6-二酮, 5-(1-苯基-3-苯基丙基-2-炔基)-2,2-亚戊基-1,3-二噁烷-4,6-二酮衍生物
A convenient and efficient approach for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-pentylidene-1,3- dioxane-4,6-dione derivatives through a three-component reaction of aldehydes with 2,2-pentylidene-1,3-dioxane-4,6-dione and arylacetylene in the presence of Cu(OAc)2·H2O/Cu is described with 12 examples. The reaction tolerates a wide range of aldehydes furnishing the products with good to excellent isolated yields (65%~88%). Additionally, the synthetic protocol has the advantages of wild conditions, simple operation, and excessive copper reused.
Key words: multicomponent reaction, copper acetate/copper, 2,2-pentylidene-1;3-dioxane-4;6-dione, 5-(1-phenyl-3-phe- nylprop-2-ynyl)-2;2-pentylidene-1;3-dioxane-4,6-dione derivatives
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