摘要/Abstract
综合运用多种现代色谱学分离方法对红树来源真菌Penicillium citrinum HL-5126中的次级代谢产物进行了研究，从中分离获得2个新的异香豆素类化合物，通过1D NMR，2D NMR和HR-ESI-MS等波谱鉴定技术确定结构分别为penicimarin J（1）和penicimarin K（2）.通过测定圆二色谱并与文献数据对照，确定了化合物1和2的绝对构型.化合物1和2对α-Glucosidase显示一定的抑制活性，IC50值分别为18.37和25.86μg/mL.
关键词: Penicillium citrinum, 异香豆素, 抗菌活性, α-Glucosidase抑制活性
Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC50 values of 18.37 and 25.86 μg/mL, respectively.
Key words: Penicillium citrinum, isocoumarin, antibacterial activity, α-glucosidase inhibitory activity
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