摘要/Abstract

以取代苯胺为起始原料，经重氮化、Meerwein芳基化、异硫氰化、加成、甲基化、环化等多步反应合成一系列结构新颖的4-芳氨基嘧啶类衍生物，并测试了目标化合物的杀虫活性.初步杀虫活性结果表明，在质量浓度500 mg/L时，大部分化合物对粘虫的致死率为100%；当质量浓度降至20 mg/L时，2-甲基-4-[N-（2-氯-4-氟苯基）氨基]-5-[2-三氟甲基-4-（苯氧基）苯基]-6-甲基嘧啶（6h）对粘虫和小菜蛾的致死率分别为80%和60%.
关键词: 4-芳氨基嘧啶, 嘧啶胺, 合成, 杀虫活性
A series of novel 4-arylamino pyrimidine derivatives were synthesized using substituted aniline as starting material via diazotization, Meerwein arylation, isothiocyanation, addition, methylation and cyclization. The preliminary results of insecticidal activities indicated that most of the compounds exhibited 100% insecticidal activitiy against Mythimna separata Walker at 500 mg/L. At 20 mg/L, N-(2-chloro-4-fluorophenyl) -2,6-dimethyl-5-(4-phenoxy-2-(trifluoromethyl) phenyl) -pyrimidin-4-amine (6h) exhibited 80% and 60% mortality against Mythimna separata Walker and Plutella xylostella Linnaeus, respectively.
Key words: 4-arylamino pyrimidine, pyrimidinamine, synthesis, insecticidal


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