摘要/Abstract
在葡萄糖酸的催化作用下，以4-甲酰基苯基-2，3，4，6-O-四乙酰基-β-D-葡萄糖苷和1，3-二噁烷-4，6-二酮为原料，发生Knoevenagel缩合反应合成了10种新型天麻素中间体类似物.该反应具有收率高（78%~92%）、反应温和、操作简单及环境友好等优点.此外，葡萄糖酸还可重复使用.
关键词: 葡萄糖酸, Knoevenagel反应, 4-甲酰基苯基-2,3,4,6-O-四乙酰基-β-D-葡萄糖苷, 天麻素中间体类似物
Ten gastrodine intermediate analogues were synthesized by the Knoevenagel reaction of 4-formylphenyl(2,3,4,6-tetra-O-acetyl)-β-D-glucoside and 1,3-dioxane-4,6-dione with gluconic acid as a catalyst. In this reaction there are many advantages with good to excellent yields (78%~92%), mild conditions, simple operations and environmental friendliness. Additionally, gluconic acid could be recycled and reused many times without lossing its efficiency.
Key words: gluconic acid, Knoevenagel reaction, 4-formylphenyl (2,3,4,6-tetra-O-acetyl)-β-D-glucoside, gastrodine intermediate analogues
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