摘要/Abstract
发展了一种新型的盐酸促进、铜/铁共催化2-取代丙烯酸酯与膦氧类化合物脱酯氧膦化反应构建β-羰基氧膦化合物，并且该反应抑制了羟膦化产物的形成.通过这种简便且实用的方法，可选择性断裂C（sp2）-C（C=O）得到结构多样化的β-羰基氧膦化合物.这类反应具有底物适用范围广泛、官能团耐受性好且反应条件温和等优点.
关键词: β-羰基氧膦化合物, 2-取代丙烯酸酯, 盐酸, 铜/铁共催化, 氧气
An unprecedented method for the transformation of 2-substituted acrylates into β-ketophosphine oxides has successfully been developed via hydrochloric acid-promoted copper/iron-cocatalyzed deesterificative oxyphosphorylation under dioxygen atmosphere, simultaneously inhibiting the formation of the preceding hydroxyphosphorylation products. Through this convenient and practical process, a library of structurally diverse β-ketophosphine oxides could be selectively and effectively obtained with broad substrate scope and good functional group tolerance under mild conditions, accompanied by chemoselective cleavage of C(sp2)-C(C=O) bonds.
Key words: β-ketophosphine oxides, 2-substituted acrylates, hydrochloric acid, copper/iron-cocatalysis, dioxygen
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