摘要/Abstract
报道了钯催化咖啡因或尿嘧啶C-H与芳烃C-H的脱氢偶联反应.反应最大特点是采用常压氧气作为唯一氧化剂.反应对很多官能团，比如卤素、酯基、硝基、腈基、醚等，都有很好的容忍度.本方法为制备C6-芳基尿嘧啶或C8-芳基咖啡因衍生物提供了简便、直接和绿色经济路线.
关键词: 钯, 咖啡因, 尿嘧啶, C-H键, 芳基化, 氧气
Palladium-catalyzed cross-dehydrogenative coupling of uracil or caffeine with unactivated arenes has been developed. The approach was characterized by using atmospheric pressure of molecular oxygen as the sole oxidant. Functional groups such as halo, ester, nitro, nitrile and ether are well-tolerated under the reaction conditions. This novel strategy provides a straightforward, facile and economical route to C6-aryl uracil derivatives or C8-aryl caffeine derivatives.
Key words: palladium, caffeine, uracil, C-H bond, arylation, oxygen
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