摘要/Abstract
将手性脲衍生物用于有机催化α-萘酚和14种芳香醛亚胺的不对称aza-Friedel-Crafts反应，筛选出最佳的催化条件，以70%~86%的化学产率和最高达78%ee的对映选择性获得了手性氨基萘酚化合物，拓宽了该反应的催化剂类型和底物范围.
关键词: 手性脲衍生物, 不对称催化, α-萘酚, aza-Friedel-Crafts反应
Chiral urea derivatives as organocatalysts were applied in the asymmetric aza-Friedel-Crafts reaction of α-naphthol with 14 N-tosyl aldimines. The desired chiral aminoarylnaphthols were obtained in 70%~86% yields with up to 78% enantiomeric excess (ee) under the screened optimal condition. The catalyst type and the substrate scope were broadened in this methodology.
Key words: chiral urea derivatives, asymmetric catalysis, α-naphthol, aza-Friedel-Crafts reaction
PDF全文下载地址:
点我下载PDF
