姓名:
胡有洪性别:
男
职称:
研究员学历:
博士
电话:
50806600-3526传真:
50805896
电子邮件:
yhhu@mail.shcnc.ac.cn个人主页:
通讯地址:
上海市浦东新区祖冲之路555号 201203
简历：
1991年毕业于兰州大学化学系，1994年获兰州大学理学硕士学位，1997年获中国科学院上海药物所理学博士学位。1997年9月至1998年8月在日本名古屋大学生命农学院MinoruIsobe研究组做访问学者；1998年9月至2000年8月在美国乔治城大学医学中心做博士后；2000年9月至2001年3月在美国哈佛大学医学院化学生物学研究所做博士后；2001年在美国Vivoquest公司担任药物化学资深研究员。2005年获中国科学院“百人计划”资助，回国任中国科学院上海药物研究所研究员、博士研究生导师。2006年获上海市“浦江人才计划”资助。
研究方向：
- 类天然产物和类药性骨架合成的新方法技术与高质量多样性小分子库的构建。
- 新型活性化合物的发现与优化及候选药物的开发。
专家类别：
研究员；百人计划
职务：
中国科学院上海药物所研究员、博士生导师、课题组长
科研成果：
承担科研项目情况：
承担及参与多项国家自然科学基金项目、科技部新药创制重大专项课题及上海市科委的重大科学研究项目。
社会任职：
获奖及荣誉：
2010年中国药学会—赛诺菲安万特青年生物药物奖
代表论著：
- HongChen,FuchunXie,JianGong,andYouhongHu*,DominoReactiontoFunctionalized2-HydroxybenzophenonesfromElectron-DeficientChromonesand1,3-DicarbonylCompoundsJ.Org.Chem.,2011,76(20),8495–8500.
- FuchunXie,HongbingZhao,DewenLi,HongChen,HaitianQuan,XiaojingShi,LiguangLou*,andYouhongHu*,SynthesisandBiologicalEvaluationof2,4,5-SubstitutedPyrimidinesasaNewClassofTubulinPolymerizationInhibitorsJ.Med.Chem.2011,54(9),3200-3205.
- YangLiu,LipingHuang,FuchunXie,XuxingChenandYouhongHu*,SynthesisofnovelfunctionalpolycyclicchromonesthroughMichaeladditionanddoublecyclizationsOrg.Biomol.Chem.,2011,9(8),2680-2684.
- DewenLi,ShudongDuan,andYouhongHu*,Three-ComponentOne-PotApproachtoSynthesizeBenzopyrano[4,3-d]pyrimidines,J.Comb.Chem.,2010,12(6),895-899.
- Xiao-dongZhang,Jian-weiYan,Gui-ruiYan,Xiao-yunSun,JunJi,Yi-mingLi,You-hongHu*,He-yaoWang*,Pharmacologicalinhibitionofdiacylglycerolacyltransferase1reducesbodyweightgain,hyperlipidemia,andhepaticsteatosisindb/dbmice,ActaPharmacologicaSinica,2010,31,1470-1477.
- YangLiu,LipingHuang,FuchunXie,andYouhongHu*,Base-PromotedOne-PotTandemReactionof3-(1-Alkynyl)chromonesunderMicrowaveIrradiationtoFunctionalizedAmino-SubstitutedXanthones,J.Org.Chem.,2010,75(18),6304–6307.
- JianGong,FuchunXie,HongChenandYouhongHu*,AnEfficientApproachtoFunctionalizedBenzo[a]xanthonesthroughReactionsof2-Methyl-3-(1-alkynyl)chromoneswithElectron-DeficientChromone-FusedDienes,Org.Lett.,2010,12(17),3848–3851.
- FuchunXie,HongChen,YouhongHu*,EfficientConstructionof3C-Xanthone-Linked3C-ChromoneScaffoldbyNovelDoubleMichaelAdditionsandCyclizations,Org.Lett.,2010,12(13),3086-3089.
- FuchunXie,XuanPan,ShijunLinandYouhongHu*,Abase-promoteddesalicyloylativedimerizationof3-(1-alkynyl)chromones:Anunusualapproachto2-alkynylxanthones,Org.Biomol.Chem.,2010,8(6),1378-1381.
- LizhiZhao,FuchunXie,GangCheng,YouhongHu*,ABase-PromotedTandemReactionof3-(1-Alkynyl)chromoneswith1,3-DicarbonylCompounds:AnEfficientApproachtoFunctionalXanthones,Angew.Chem.Int.Ed.,2009,48(35),6520–6523.
- FuchunXie,HongbingZhao,LizhiZhao,LiguangLou,YouhongHu*,Synthesisandbiologicalevaluationofnovel2,4,5-substitutedpyrimidinederivativesforanticanceractivity,Bioorganic&MedicinalChemistryLetters,2009,19(1),275－278.
- XuSun,Xiao-DongZhang,GangCheng,You-HongHu*andHe-YaoWang*“Inhibitionofhepaticstellatecellproliferationbyheatshockprotein90inhibitorsinvitro”MolecularandCellularBiochemistry2009,330(1-2),181–185.
- LizhiZhao,GangChengandYouhongHu*,Anovelmulticomponentreactiontosynthesizesubstitutedfuro[3,2-c]chromenesviaaPd-catalyzedcascadeprocess,TetrahedronLetters,2008,49(52),7364-7367.
- GangCheng,andYouhongHu*,TwoEfficientCascadeReactionstoSynthesizeSubstitutedFurocoumarins,J.Org.Chem.,2008,73(12),4732-4735.
- GangCheng,ShukunLi,JingyaLiandYouhongHu*,Three-Component，One-PotSynthesisofNovel2,4-Substituted5-AzolylthiopyrimidinesLibraryforScreeningagainstAnti-influenzaVirusA,Bio.Med.Chem.Lett.,2008,18(3),1177-1180.
- GangChengandYouhongHu*,One-potSynthesisofFurocoumarinsthroughCascadeAddition-Cyclization-Oxidation,Chem.Comm.,2007,31,3285-3287.
- ShijunLin,ZhendeLiuandYouhongHu*,Microwave-EnhancedEfficientSynthesisofDiversified3,6-DisubstitutedPyridazines,J.Comb.Chem.,2007,9(5),742-744.
- ZhendeLiu,DewenLi,ShukunLi,DongluBai,XuchangHeandYouhongHu*,Synthesisofnovel5,6-substitutedfuro[2,3-d]pyrimidinesviaPd-catalyzedcyclizationofalkynylpyrimidinolswitharyliodides,Tetrahedron,2007,63(9),1931-1936.
- FuchunXie,ShukunLi,LiguangLou,DongluBaiandYouhongHu*,Three-Component,One-PotSynthesisof2,4,5-SubstitutedPyrimidinesLibraryforScreeningagainstHumanHepatocellularCarcinomaBEL-7402Cells,J.Comb.Chem.,2007,9(1),12-13.
- FuchunXie,GangChengandYouhongHu*,Three-Component,One-PotReactionfortheCombinatorialSynthesisof1,3,4-SubstitutedPyrazoles,J.Comb.Chem.,2006,8(3),286-288.
