研究队伍
姓名:
　陈笑艳性别:
　女
职称:
　研究员学历:
　博士
电话:
　021-50800738传真:
　
电子邮件:
　xychen@mail.shcnc.ac.cn个人主页:
　
通讯地址:
　上海市浦东新区海科路501号　201203

简历：
1994年毕业于沈阳药科大学，1999年获得沈阳药科大学药物分析学博士学位。现任中国科学院上海药物研究所研究员、博士研究生导师、药物代谢研究中心课题组长。

研究方向：

1. 药物代谢活化过程与药物不良反应机理研究
2. 手性药物立体选择性药动学和代谢机理研究
3. 药动学生物样品分析技术研究
4. 创新药物开发过程的药物代谢和动力学研究

专家类别：
研究员；百人计划

职务：
中科院上海药物所研究员、博士生导师、研究组长

科研成果：


承担科研项目情况：

1. 主持和参加国家自然科学基金项目
2. 国家“863”临床前药物代谢动力学关键技术及平台研究项目

社会任职：


获奖及荣誉：
“108种制剂的药物动力学和生物等效性研究”获沈阳市科技进步一等奖和辽宁省科技进步二等奖

代表论著：

1. JinH,LiL,ZhongDF,LiuJ,ChenXY*,JiangZheng*.PulmonarytoxicityandmetabolicactivationoftetrandrineinCD-1Mice.ChemResToxicol,2011,DOI:10.1021/tx200290s.
   
2. ChenMX,LiuK,ZhongDF,ChenXY*.Trimethylsilyldiazomethanederivatizationcoupledwithsolid-phaseextractionforthedeterminationofalendronateinhumanplasmabyLC-MS/MS.AnalBioanalChem,2011,DOI:10.1007/s00216-011-5467-4.
   
3. XieC,YuK,ZhongDF,YuanT,YeF,JarrellJ,MillarA,ChenXY*.Investigationofisomerictransformationsofchlorogenicacidinbuffersandbiologicalmatricesbyultraperformanceliquidchromatographycoupledwithhybridquadrupole/ionmobility/orthogonalaccelerationtime-of-flightmassspectrometry.JAgricFoodChem,2011,59:11078-11087
   
4. XieC,YangSL,ZhongDF,DaiXJ,ChenXY*.Simultaneousdeterminationofdronedaroneanditsactivemetabolitedebutyldronedaroneinhumanplasmabyliquidchromatography–tandemmassspectrometry:Applicationtoapharmacokineticstudy.JChromatogrB,2011,879:3071-3075
   
5. DengP,ZhongDF,NanFJ,LiuS,LiD,YuanT,ChenXY*,ZhengJ*.Evidenceforthebioactivationof4-nonyphenoltoquininemethideandortho-benzoquinonemetabolitesinhumanlivermicrosomes.ChemResToxicol,2010,23:1617-1628
   
6. LiuK,ZhongDF,ChenXY*.Enantioselectivedeterminationofdoxazosininhumanplasmabyliquidchromatography-tandemmassspectrometryusingovomucoidchiralstationaryphase.JChromatogrB,2010,878:2415-2420
   
7. LiuK,ZhongDF,ZouHY,ChenXY*.Determinationoftegafur,5-fluorouracil,gimeracilandoxonicacidinhumanplasmausingliquidchromatography-tandemmassspectrometry.JPharmBiomedAnal,2010,52:550-556
   
8. LiuK,ZhongDF,ChenXY*.EnantioselectivequantificationofchiraldrugsinhumanplasmawithLC–MS/MS.Bioanalysis,2009,1:561-576
   
9. WangYY,ZhongDF,ChenXY*,ZhengJ*.Identificationofquinonemethidemetabolitesofdauricineinhumanlivermicrosomesandinratbile.ChemResToxicol,2009,22:824-834
   
10. LiuK,DaiXJ,DengP,MaJF,ZhongDF,ChenXY*.Simultaneousdeterminationof6R-leucovorin,6S-leucovorinand5-methyltetrahydrofolateinhumanplasmausingchiralliquidchromatography-tandemmassspectrometry.JChromatogrB,2009,877:902-910
    
11. ZhangHC,ZhongDF,ZhangZZ,DaiXJ,ChenXY*.Liquidchromatography/tandemmassspectrometrymethodforthequantificationofdeserpidineinhumanplasma:Applicationtoapharmacokineticstudy.JChromatogrB,2009,877:3221-3225
    
12. DengP,ZhongDF,ChenXY*.Determinationoftropisetroninhumanplasmabyliquidchromatography–tandemmassspectrometry.JPharmBiomedAnal,2009,49:848-852
    
13. LiuK,DaiXJ,ZhongDF,ChenXY*.Quantitativedeterminationofondansetroninhumanplasmabyenantioselectiveliquidchromatography-tandemmassspectrometry.JChromatogrB,2008,864:129-136
    
14. DuanXT,ZhongDF,ChenXY*.Derivatizationofbeta-dicarbonylcompoundwith2,4-dinitrophenylhydrazinetoenhancemassspectrometricdetection:Applicationinquantitativeanalysisofhouttuynininhumanplasma.JMassSpectrom,2008,43:814-824
    
15. ZhongS,ZhongDF,ChenXY*.Improvedandsimplifiedliquidchromatography/electrosprayionizationmassspectrometrymethodfortheanalysisofunderivatizedglucosamineinhumanplasma.JChromatogrB,2007,854:291-298
    
16. GaoJ,ZhongDF,DuanXT,ChenXY*.Liquidchromatography/negativeionelectrospraytandemmassspectrometrymethodforthequantificationofrosuvastatininhumanplasma:Applicationtoapharmacokineticstudy.JChromatogrB,2007,856:35-40
    
17. ChenXY,DengP,DaiXJ,ZhongDF.Simultaneousdeterminationofamodiaquineanditsactivemetaboliteinhumanbloodbyion-pairliquidchromatography-tandemmassspectrometry.JChromatogrB,2007,860:18-25
    
18. ChenXY,DuanXT,DaiXJ,ZhongDFDevelopmentandvalidationofaliquidchromatographic/tandemmassspectrometricmethodforthedeterminationofsertralineinhumanplasma.RapidCommunicationsinmassspectrometry,2006,20:2483-2489
    
19. ChenXY,LiuD,LuanY,ZhongDF.Determinationofzolmitriptaninhumanplasmabyliquidchromatography-tandemmassspectrometrymethod:Applicationtoapharmacokineticstudy.JChromatogrB,2006,832:30-35
    
20. ChenXY,CuiL,DuanXT,ZhongDF.Pharmacokineticsandmetabolismoftheflavonoidscutellarininhumansafterasingleoraladministration.DrugMetabDispos,2006,34:1345-1352