研究队伍
姓名:
　许叶春性别:
　女
职称:
　研究员学历:
　博士
电话:
　传真:
　
电子邮件:
　ycxu@mail.shcnc.ac.cn个人主页:
　http://www.dddc.ac.cn/group/yechun_xu.htm
通讯地址:
　上海市祖冲之路555号　201203

简历：
许叶春研究员1999年毕业于华东师范大学，获理学学士学位；2001年毕业于华东师范大学，获理学硕士学位；2004年在上海药物研究所获理学博士学位。博士毕业后留所工作一年。2005年至2009年在以色列魏茨曼科学研究所从事博士后研究工作。2009年获“中国科学院引进国外杰出人才计划”（百人计划）资助进入上海药物研究所药物发现与设计中心担任结构生物学组课题组长。


研究方向：
采用结构生物学和计算生物学的多种方法对老年痴呆症密切相关的重要药物靶标以及其他重大疾病相关的膜蛋白的结构功能进行研究，并基于此进行药物设计和改造。

专家类别：
研究员；百人计划

职务：
课题组长

科研成果：


承担科研项目情况：


社会任职：


获奖及荣誉：

1. CAS-NovoNordiskGreatWallProfessorship(2009)
2. DeanofFaculty’sFellowship,WeizmannInstituteofScience(2005-2008)
3. Awardsforthenationaltop-100excellentdoctoraldissertations(2006)
4. SERVIERyounginvestigatorawardsprizeinmedicinalchemistry(2005)
5. “Baojie”scholarshipforoutstandingPhDstudents(2003)
6. “ZhongShanWuMao”scholarshipforoutstandinggraduatestudents(2000)
7. Thehonorsof“inventionSanQiangBeiinShanghai”(2000)
8. ThehonorsofexcellentgraduateoftheEastChinaNormalUniversity(1999)
9. Thirdprizeofthesixthnationalsession“TiaoZhanBei”(1999)

代表论著：

1. YechunXu,JacquesPh.Colletier,MartinWeik,HualiangJiang,JohnMoult,IsraelSilman,JoelL.Sussman.Flexibilityofaromaticresiduesintheactive-sitegorgeofacetylcholinesterase:X-rayvsMD.Biophys.J.2008,95,2500-2511.
2. YechunXu,JacquesPh.Colletier,HualiangJiang,IsraelSilman,JoelL.Sussman,MartinWeik.Induced-fitofpreexistingequilibriumdynamics?LessonsfromproteincrystallographyandMDsimulationsonacetylcholinesteraseandimplicationsforstructure-baseddrugdesign.Prot.Sci.2008,17,601-605.
3. XinliLiu,YechunXu,HonglinLi,XichengWang,HualiangJiang,FranciscoJ.Barrantes.Mechanicsofchannelgatingofthenicotinicacetylcholinereceptor.PLoSComput.Biol.2008,4,e19.
4. YechunXu,FranciscoJ.Barrantes,JianhuaShen,XiaominLuo,WeiliangZhu,KaixianChen,HualiangJiang.Blockingofthenicotinicacetylcholinereceptorionchannelbychlorpromazine,anoncompetitiveinhibitor:amoleculardynamicssimulationstudy.J.Phys.Chem.B2006,110,20640-20648.
5. DongxiangLiu,YechunXu,YuFeng,HongLiu,XuShen,KaixianChen,JianpengMa,HualiangJiang.Inhibitordiscoverytargetingtheintermediatestructureof?-Amyloidpeptideontheconformationaltransitionpathway:implicationsintheaggregationmechanismof?-amyloidpeptide.Biochemistry2006,45,10963-10972.
6. YechunXu,XiaominLuo,JianhuaShen,WeiliangZhu,KaixianChen,HualiangJiang.Moleculardynamicsofnicotinicacetylcholinereceptorcorrelatingbiologicalfunctions.CurrentProteinandPeptideScience2006,7,195-200(review).
7. YechunXu,JianhuaShen,XiaominLuo,WeiliangZhu,KaixianChen,JianpengMa,HualiangJiang.Conformationaltransitionofamyloid?-peptide.PNAS2005,102,5403-5407.
8. YechunXu,FranciscoJ.Barrantes,XiaominLuo,KaixianChen,JianhuaShen,HualiangJiang.Conformationaldynamicsofthenicotinicacetylcholinereceptorchannel:a35-nsmoleculardynamicssimulationstudy.J.Am.Chem.Soc.2005,127,1291-1299.
9. YechunXu,JianhuaShen,WeiliangZhu,XiaominLuo,KaixianChen,HualiangJiang.Influenceofwatermoleculeoncation-?interaction:abinitiosecondorderM?ller-Plessetperturbationtheory(MP2)calculations.J.Phys.Chem.B.2005,109,5945-5949.
10. YechunXu,JianhuaShen,XiaominLuo,XuShen,KaixianChen,HualiangJiang.Steeredmoleculardynamicssimulationsofprotein-ligandinteractions.ScienceinChinaSer.BChemistry,2004,47:355-366(review).
11. YechunXu,JianhuaShen,XiaominLuo,IsraelSilman,JoelL.Sussman,KaixianChen,HualiangJiang.HowdoeshuperzineAenterandleavethebindinggorgeofacetylcholinesterase?steeredmoleculardynamicssimulation.J.Am.Chem.Soc.2003,125,11340-11349.